Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Evaluation of Long Term Prognosis in Patients Treated with Narrowband Ultraviolet B: A Retrospective Study for 8 Years
Dar-Band Ultraviyole B ile Tedavi Edilen Hastalarda Uzun Dönem Prognozun Değerlendirilmesi: 8 Yıllık Retrospektif Bir Çalışma
Gül Aslıhan ÇAKIR AKAYa, Dilsun YILDIRIMb, Fatma GÜLRU ERDOĞANa, İrem KARc
aDepartment of Dermatology, Ufuk University Faculty of Medicine, Ankara, TURKEY
bClinic of Dermatology, Şırnak State Hospital, Şırnak, TURKEY
cDepartment of Biostatistics, Ankara University Faculty of Medicine, Ankara, TURKEY
Turkiye Klinikleri J Med Sci. 2019;39(4):353-61
doi: 10.5336/medsci.2019-66821
Article Language: EN
Full Text
ABSTRACT
 Objective: Narrow-band ultraviolet B (NB-UVB) is a proven treatment modality in the management of psoriasis, inflammatory skin diseases and pigmentation disorders. However, recurrence is an important problem both for the patient and the clinician. The long-term effects of narrow-band ultraviolet B treatment on different dermatological indications cause concern. The aim of this study is to evaluate the effectiveness and the recurrence rates of the NB-UVB treatment in several dermatological diseases. Material and Methods: A total of 126 patients aged 18 years or older who received narrow-band ultraviolet B treatment due to various indications were included in the study. Treatment response and recurrence rates were retrospectively evaluated and compared in different disease groups. In addition, a statistical comparison was made between the recurrent and non-recurrent groups in terms of some variables that might affect relapse. Results: Complete remission, partial remission and unresponsiveness were detected in 74.6%, 13.5% and 11.9% of the patients respectively. The mean follow up period was 27.3±23.8 months. Recurrence was observed in 46.8% of patients with complete remission. Of the patients who developed recurrence, 59.1% had psoriasis, 13.6% mycosis fungoides, 13.6% atopic dermatitis, 6.8% vitiligo and 6.8% idiopathic pruritus. Conclusion: Based on our study findings, narrow-band ultraviolet B treatment may reduce the relapse rate in all dermatoses when scheduled in the early period. In addition to its widespread use in the treatment of psoriasis, it would be beneficial to consider narrow-band ultraviolet B as an effective treatment method in patients with idiopathic pruritus in the long-term period.

Keywords: Ultraviolet therapy; recurrence
ÖZET
 Amaç: Dar band ultraviyole B başta psoriasis, inflamatuvar deri hastalıkları ve pigmentasyon bozukluklarının tedavisinde etkinliği kanıtlanmış bir tedavi yöntemidir. Bununla birlikte hem hasta hem klinisyen için nüks bir sorun olup, farklı dermatolojik endikasyonlarda dar band ultraviyole B tedavisinin uzun dönem etkileri merak konusudur. Bu çalışmanın amacı çeşitli dermatolojik hastalıklarda dar band ultraviyole B tedavisinin etkinliğinin ve nüks oranlarının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmaya kliniğimizde çeşitli tanılarla dar band ultraviyole B tedavisi almış 18 yaş üstü 126 hasta dahil edildi. Tedavi yanıtı ve nüks farklı hastalıklarda retrospektif olarak değerlendirildi ve karşılaştırıldı. Ayrıca nüks olan ve olmayan gruplar arasında nüksü etkileyebilecek bazı değişkenler açısından istatistiksel karşılaştırma yapıldı. Bulgular: Hastaların %74,6'ünde komplet remisyon, %13,5'ünde parsiyel remisyon %11,9' unda tedaviye yanıtsızlık saptandı. Ortalama takip süresi 27,29±23,8 aydı. Komplet remisyondaki hastaların %46,8'inde nüks mevcuttu. Nüks gelişen hastaların %59,1'i psoriasis %13,6'sı mikozis fungoides, %13,6'sı atopik dermatit, %6,8'i vitiligo ve %6,8'i idyopatik pruritus idi. Sonuç: Çalışma bulgularımız ışığında dar band ultraviyole B tedavisinin tüm dermatozlarda erken dönemde planlanması relaps oranını azaltabilecektir düşüncesindeyiz. Ayrıca psoriasis tedavisinde yaygın kullanımının yanı sıra, dar band ultraviyole B'nin idyopatik prurituslu hastalarda da uzun dönemde etkin bir tedavi ajanı olarak göz önünde bulundurulması faydalı olacaktır.

Anahtar Kelimeler: Ultraviyole tedavisi; nüks
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