Objective: This study aims to evaluate the effects of omalizumab on hematological parameters and inflammation biomarkers in patients diagnosed with chronic spontaneous urticaria (CSU). Material and Methods: The records of 109 (76 women and 33 men) patients, who were treated with omalizumab with the diagnosis of CSU were retrospectively examined. In addition, the pre-treatment and postomalizumab treatment periods were evaluated in CSU patients by comparing hematological, inflammatory and biochemical parameters. The data of these patients were compared to a healthy control group with similar characteristics such as age and gender. Results: C-reactive protein (CRP), neutrophil (NEU), and monocyte values were significantly higher in patients with CSU, while basophil values in control individuals. The comparison of the measurements of the patients before and after omalizumab treatment revealed a significant reduction in CRP, white blood cell (WBC), NEU, and platelet (PLT) levels. WBC, NEU, and eosinophil levels were found to be significantly reduced in responders compared to non-responders to treatment. Conclusion: The evaluation of CRP, NEU, PLT levels are found to be important to show the activity of the disease in CSU. We think that these inflammatory markers are important in the follow-up of CSU and omalizumab treatment. We think that these inflammatory markers are important in the follow-up of CSU and omalizumab treatment. Our results will contribute to the medical literature to establish both the mechanism of action of omalizumab and the parameters used in the follow-up of omalizumab therapy in patients with CSU.
Keywords: Omalizumab; chronic urticaria; inflammation
Amaç: Bu çalışmada, kronik spontan ürtiker (KSÜ) tanılı hastalarda omalizumabın hematolojik parametreler ve inflamasyon biyobelirteçleri üzerine olan etkilerinin değerlendirmesi amaçlanmaktadır. Gereç ve Yöntemler: KSÜ tanısıyla omalizumab ile tedavi edilmiş 109 (76 kadın, 33 erkek) hastanın hastane kayıtları retrospektif olarak incelendi. Ayrıca hastalarda tedavi öncesi ve omalizumab tedavisi sonrası dönemde hematolojik, inflamatuar ve biyokimyasal parametreler karşılaştırılarak değerlendirildi. Bu hastaların verileri yaş ve cinsiyet gibi benzer özelliklere sahip sağlıklı kontrol grubu ile karşılaştırıldı. Bulgular: C-reaktif protein (CRP), nötrofil (NEU), monosit değerleri KSÜ'lü hastalarda ve bazofil değeri ise kontrol bireylerinde anlamlı düzeyde daha yüksek olduğu görüldü. Hastalarda omalizumab tedavisi öncesi ve sonrası ölçümleri karşılaştırıldığında CRP, beyaz kan hücresi [white blood cell (WBC)], NEU ve platelet (PLT) düzeylerinde anlamlı azalma tespit edildi. Tedaviye yanıt veren hastalarda WBC, NEU, EOS düzeyleri, yanıt vermeyenlerle karşılaştırıldığında anlamlı düzeyde azaldığı bulundu. Sonuç: KSÜ'de hastalığın aktivitesini göstermek için CRP, NEU, PLT düzeylerinin değerlendirilmesinin önemli olduğu bulundu. KSÜ ve omalizumab tedavisinin takibinde bu inflamatuar belirteçlerinin önemli olduğunu düşünmekteyiz. Sonuçlarımız, KSÜ hastalarında hem omalizumabın etki mekanizmasını hem de omalizumab tedavisinde takipte kullanılan parametreleri oluşturmak için tıbbi literatüre katkıda bulunacaktır.
Anahtar Kelimeler: Omalizumab; kronik ürtiker; inflamasyon
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