Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Evaluation of Effects of Melatonin on Myofascial Pain: A Preliminary Study
Melatoninin Miyofasiyal Ağrı Üzerine Etkilerinin Araştırılması: Ön Çalışma
Muazzez SÜZENa , Çağrı DELİLBAŞIa
aDepartment of Oral and Maxillofacial Surgery, İstanbul Medipol University Faculty of Dentistry, İstanbul, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(3):385-92
doi: 10.5336/dentalsci.2022-94834
Article Language: EN
Full Text
ABSTRACT
 Objective: To compare effects of melatonin with that of nonsteroidal anti-inflammatory drugs (NSAIDs) and behavioral therapy on patients sustaining myofascial pain. Material and Methods: A total of 45 patients were included and assigned into 3 groups; a melatonin (6 mg) group, a NSAID group and a behavioral treatment group. Preoperative, first- and third-month clinical parameters (masticatory muscle pain, temporomandibular joint region pain, facial pain, amount of mouth opening) were assessed using Research Diagnostic Criteria for Temporomandibular Disorders form retrospectively. Besides, sleep quality was assessed using Visual Analog Sleep Quality Scale at the same periods. Results: Following assessment of records of 300 (224 females and 76 males) patients 45 of them who met the inclusion criteria were included in the study. In the first month, facial pain decreased significantly in the melatonin group compared to other two groups (p1: 0.011; p2: 0.044). Mouth opening did not differ between the NSAID and the melatonin group (p>0.05), but was significantly lower in the behavioral treatment group (p1: 0.000; p2: 0.004; p<0.05). Considering muscle and temporomandibular joint pain, the melatonin group showed the least pain level. In the first and third months, sleep quality scores was did not show significant difference between the treatment groups (p>0.05), but increased significantly higher in the melatonin group compared to other two groups (p: 0.000; p<0.05). Conclusion: Complaints subsided in all the treatment groups. Melatonin can be considered as an agent that has analgesic and anti-inflammatory effects in myofascial pain. Further studies in this field are necessary those evaluate different regimens and routes of melatonin use.

Keywords: Temporomandibular joint; temporomandibular disorders; facial pain; melatonin
ÖZET
 Amaç: Miyofasiyal ağrılı hastalarda melatoninin etkilerinin nonsteroid antiinflamatuar (NSAİİ) ilaçlarla ve davranışsal terapiyle karşılaştırılmasıdır. Gereç ve Yöntemler: Bu çalışma için toplam 45 hasta; melatonin (6 mg) grubu, NSAİİ grubu ve davranışsal terapi grubu olmak üzere 3 gruba ayrıldı. Temporomandibular Rahatsızlıklar için raştırma Teşhis Kriterleri formu kullanılarak preoperatif ve 1. ay, 3. ay klinik parametreleri (çiğneme kaslarında ağrı, temporomandibular eklem bölgesinde ağrı, yüz ağrısı, ağız açıklığı miktarı) retrospektif olarak değerlendirildi. Ayrıca, aynı periyotlarda uyku kalitesi Görsel Analog Uyku Kalite Skalası kullanılarak değerlendirildi. Bulgular: Bu çalışma için 300 (224 kadın, 76 erkek) hastanın değerlendirilmesi sonucu 45 hastanın dâhil edilmesine karar verildi. Birinci ayda melatonin grubunda fasiyal ağrı diğer 2 gruba göre anlamlı derecede azaldı (p1: 0,011; p2: 0,044). Ağız açıklığı miktarı, NSAİİ ve melatonin gruplarında farklı değilken (p>0,05), davranışsal terapi grubunda anlamlı derece azalmıştı (p1: 0,000; p2: 0,004; p<0,05). Çiğneme kasları ve temporomandibular eklem ağrısı açısından, en az ağrı seviyesi melatonin grubunda görüldü. Birinci ve 3. aylarda, uyku kalitesi gruplar arasında farklı bulunmadı (p>0,05), ancak; melatonin grubunda uyku kalitesindeki artış diğer 2 gruptan daha fazlaydı (p: 0,000; p<0,05). Sonuç: Bütün gruplarda hasta şikâyetlerinin azaldığı görüldü. Melatonin, analjezik ve antiinflamatuar etkileriyle miyofasiyal ağrıda kullanılabilecek bir ajan olarak düşünülebilir. Bu alanda melatonin farklı dozlarına ve uygulama şekillerine göre ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Temporomandibular eklem; temporomandibular düzensizlikler; fasiyal ağrı; melatonin
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