Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Evaluation of Dry Eye, Central Corneal and Epithelial Thickness in Psoriasis Patients: Case Control Study
Psöriyazisli Hastalarda Kuru Gözün, Santral Korneal ve Epitelyal Kalınlığın Değerlendirilmesi: Olgu Kontrol Çalışması
Elif YUSUFOĞLUa , Neşe GÖÇER GÜROKb
aElazığ Fethi Sekin City Hospital, Clinic of Ophthalmology, Elazığ, Türkiye
bElazığ Fethi Sekin City Hospital, Clinic of Dermatology, Elazığ, Türkiye
Turkiye Klinikleri J Ophthalmol. 2024;33(1):56-61
doi: 10.5336/ophthal.2023-100257
Article Language: EN
Full Text
ABSTRACT
 Objective: The evaluation of diagnostic tests for dry eye, mean central corneal and epithelial thickness in psoriasis patients. Material and Methods: The study was conducted with 54 psoriasis patients and 51 healthy volunteers. Psoriasis was diagnosed based on clinical findings and histopathological examination of the lesions. Those who were under systemic psoriasis treatment drugs were not included in the study. In all cases, in addition to routine eye examination, tear break-up time (TBUT), anesthetized Schirmer test, and corneal fluorescein staining (CFS) score were evaluated. In addition, mean central corneal thickness (CCT), and mean central corneal epithelial thickness (CCET) were measured by anterior segment optical coherence tomography. The study parameters were compared between the two groups. Results: The mean age of the psoriasis patients was 37.85 ± 12.44 and the mean age of the control group was 39.96 ± 10.11. (p=0.331) There were 36 (66.7%) women and 18 (33.3%) men in the psoriasis group, and 36 (70.6%) women and 15 (29.4%) men in the control group. (p=0.665) TBUT was significantly lower (p=0.011) and CFS score was significantly higher (p=0.039) in the psoriasis group when compared to the control group. No significant difference was determined in the Schirmer test, CCT, and CCET between the two groups (p>0.05). Conclusion: Dry eye is common in psoriasis, especially due to impaired tear stability, and could negatively affect the ocular surface. In our study, no statistically significant changes were detected in CCT and CCET. However, we think that new studies are needed on this subject.

Keywords: Psoriasis; dry eye; central corneal thickness; central corneal epithelial thickness; anterior segment optical coherence tomography
ÖZET
 Amaç: Bu çalışmanın amacı, psöriyazisli hastalarda kuru göz değerlendirme testlerini, ortalama santral korneal ve epitelyal kalınlığı değerlendirmektir. Gereç ve Yöntemler: Psöriyazis tanısı olan 54 hasta ile 51 sağlıklı gönüllü çalışmaya dahil edildi. Psöriyazis tanısı klinik bulgulara ve lezyonların histopatolojik incelemesine dayanılarak konuldu. Psöriyazis nedeniyle sistemik tedavi alan olgular çalışmaya dahil edilmedi. Bütün olgularda rutin göz muayenesine ilaveten göz yaşı kırılma zamanı (GYKZ), anestezili schirmer testi, korneal floresein boyanma (KFB) skoru değerlendirildi. Ayrıca ön segment optik koherens tomografi ile ortalama santral korneal kalınlık (SKK) ve ortalama santral korneal epitelyal kalınlık (SKEK) ölçüldü. Çalışma parametreleri iki grup arasında karşılaştırıldı. Bulgular: Psöriyazisli olguların yaş ortalaması 37,85± 12,44 ve kontrol grubundaki olguların yaş ortalaması ise 39,96±10,11 idi. (p=0,331) Psöriyazis grubunun 36'sı (%66,7) kadın, 18'i (%33,3) erkek, kontrol grubunun ise 36'sı (%70,6) kadın, 15'i (%29,4) erkekti. (p=0,665) Psöriyazis grubunda kontrol grubuna kıyasla GYKZ anlamlı derecede düşük (p=0,011) ve KFB skoru ise anlamlı derecede yüksek saptandı. (p=0,039) Shirmer testi, SKK ve SKEK açısından ise iki grup arasında anlamlı bir fark saptanmadı (p>0,05). Sonuç: Psöriyaziste kuru göz sık görülen oküler bulgulardandır. Özellikle gözyaşı stabilitesinin bozulmasına bağlı ortaya çıkan kuru göz oküler yüzeyi olumsuz etkileyebilir. Bizim çalışmamızda SKK ve SKEK'da istatiksel olarak anlamlı bir değişiklik saptanmamıştır. Ancak bu konuda yeni çalışmalara ihtiyaç olduğunu düşünmekteyiz.

Anahtar Kelimeler: Psöriyazis; kuru göz; santral korneal kalınlık; santral korneal epitelyal kalınlık; anterior segment optik koherens tomografi
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