Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Evaluation of Age-Related Changes in Corneal Parameters Using Scheimpflug Imaging: A Prospective Clinical Study Scheimpflug Görüntüleme Tekniği Kullanılarak Yaşa Bağlı
Kornea Parametrelerindeki Değişikliklerin Değerlendirilmesi: Prospektif Klinik Çalışma
Mustafa DURANa
aClinic of Ophthalmology, Hitit University Erol Olçok Training and Research Hospital, Çorum, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(2):90-8
doi: 10.5336/ophthal.2022-93436
Article Language: EN
Full Text
ABSTRACT
 Objective: To determine the changes in corneal parameters of the normal population with age using corneal topography. Material and Methods: This prospective study included 275 right-eye measurements from a total of 275 healthy participants. The participants were divided into 4 groups according to their age: 6 to 20 years (Group 1), 21 to 40 years (Group 2), 41 to 60 years (Group 3), and over 60 years (Group 4). Central corneal thickness (CCT), central 10 mm corneal volume (Cvol), keratometry (K) values, corneal astigmatism (Ast), and axis values obtained with a Sirius topography device were recorded. Results: The mean age of the participants was 35.94±21.04 (range 6 to 77). There was a significant difference in CCT, Cvol, and Ast measurements between the groups (p<0.001). Regression analysis found a decrease of 4.6 µm in CCT and 0.6 mm3 in Cvol for every 10 years. There was a significant negative correlation between age and CCT and Cvol (r=-0.281, r=-0.336, respectively). There was a statistically significant change in the astigmatic axis values in accordance with with-the rule (WTR) and against-the rule with age. There was a significant difference in overall and Group 1 and 2 K values in the evaluation according to sex. Conclusion: CCT, Cvol, and Ast values decrease significantly with age. Axis values shift from WTR to against-to-rule with age. Knowledge of these changes can help in the prediction of the longterm results of corneal diseases, ophthalmic operations, and intraocular lens power calculations.

Keywords: Central corneal thickness; corneal volume; keratometry values; corneal astigmatism
ÖZET
 Amaç: Bu çalışmanın amacı, yaşla birlikte normal popülasyonun kornea parametrelerinde meydana gelen değişiklikleri korneal topografi kullanarak belirlemektir. Gereç ve Yöntemler: Bu prospektif çalışma toplam 275 sağlıklı katılımcının 275 sağ göz ölçümlerini içermektedir. Katılımcılar yaşlarına göre 4 gruba ayrıldı: 6-20 yaş (Grup 1), 21-40 yaş (Grup 2), 41-60 yaş (Grup 3), 60 yaş üzeri (Grup 4). Sirius topografi cihazı ile alınan santral kornea kalınlığı [central corneal thickness (CCT)], santral 10 mm korneal hacim [corneal volume (Cvol)], keratometri (K) değerleri, korneal astigmat [corneal astigmatism (Ast)] ve aks değerleri kaydedildi. Bulgular: Katılımcıların ortalama yaşları 35,94 (aralık, 6-77 yaş) idi. Gruplar arasında CCT, Cvol ve Ast ölçümlerinde anlamlı fark mevcut idi (p<0,001). Regresyon analizinde her 10 yıl için CCT'de 4,6 µm, Cvol'de 0,6 mm3 azalma bulundu. Yaşla CCT ve Cvol arasında anlamlı negatif korelasyon vardı (sırasıyla, r=-0,281, r=-0,336). Düz K değerinde Grup 2 ve 3 arasındaki farktan kaynaklanan anlamlılık mevcut idi. Yaşla birlikte kurala uygun ve kurala aykırı astigmatik aks değerlerinde istatistiksel olarak anlamlı değişiklik var idi. Cinsiyetle ilişkili değerlendirmede tüm katılımcılar, Grup 1 ve 2'de K değerleri açısından anlamlı fark mevcut idi. Sonuç: CCT, Cvol ve Ast değerleri yaşla anlamlı olarak azalmaktadır. Aks değerleri yaşla birlikte kurala uygun astigmattan, kurala aykırı astigmata kaymaktadır. Bu değişimlerin bilinmesi cerrahi girişimlerin, göz içi lens gücü hesaplamalarının, kornea hastalıklarının, uzun dönem sonuçlarının tahmin edilebilmesinde yardımcı olabilir.

Anahtar Kelimeler: Santral kornea kalınlığı; kornea hacmi; keratometri değerleri; korneal astigmat
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