Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Evaluation of 25-HydroxyVitamin D Levels in Patients with Chronic Telogen Effluvium: A Retrospective Analysis of 291 Cases
Kronik Telogen Effluvium Hastalarında 25 Hidroksi Vitamin D Düzeylerinin Değerlendirilmesi: 291 Olguluk Retrospektif Analiz
Funda KEMERİZa, Sibel Çiğdem TUNCERb, Burcu TUĞRULc
aDepartment of Dermatology, Aksaray University Faculty of Medicine, Aksaray, TURKEY
bDepartment of Biochemistry, Aksaray University Faculty of Medicine, Aksaray, TURKEY
cDepartment of Dermatology, University of Health Science Ankara Oncology Training and Research Hospital, Ankara, TURKEY
Turkiye Klinikleri J Dermatol. 2020;30(3):69-73
doi: 10.5336/dermato.2020-77786
Article Language: EN
Full Text
ABSTRACT
 Objective: Telogen effluvium is a common diluted, nonscarring, and frequently observed hair loss type classified into acute (less than 6 months) and chronic (more than 6 months). Some etiological reasons are hypothesized to contribute to telogen effluvium pathogenesis, one of which is the vitamin D inadequacy. Various researches stated conflicting consequences on 'serum 25 hydroxy vitamin D' (25-OH vitamin D) levels, and also relationship regarding telogen effluvium. In this retrospective analysis, it is targeted to evaluate and compare serum '25-OH vitamin D' levels in chronic telogen effluvium patients with control group in a large research group. Material and Methods: Results of serum 25-OH vitamin D levels in 291 chronic telogen effluvium patients and 258 healthy individuals were evaluated retrospectively and compared to each other. Results: A statistically significantly lower serum amount of 25-OH vitamin D was observed in patients of chronic telogen effluvium compared with the stable control group (p<0.001). Prevalence of vitamin D deficiency was seen to be 82.1% in chronic telogen effluvium patient group. Conclusion: Based on these findings, it is believed that serum 25-OH levels of vitamin D may be routinely evaluated in patients with chronic telogen effluvium and vitamin D supplementation choice for such patients can be recommended for further research.

Keywords: Vitamin D; telogen effluvium; vitamin D deficiency; hair disorder
ÖZET
 Amaç: Telogen effluvium skar yapmayan, yaygın tutulumlu ve toplumda yaygın görülen saç dökülmesi tipi olup; 6 aydan kısa sürenler akut, 6 aydan uzun sürenler kronik olarak sınıflandırılır. Birçok faktörün telogen effluvium patogenezi için katkıda bulunduğu üzerinde düşünülmüş olup bunlardan bir tanesi vitamin D eksikliğidir. Serum 25 hydroksi vitamin D (25-OH vitamin D) düzeyi ile telogen effluvium arasındaki ilişkiyi araştıran önceki çalışmaların sonuçları çelişkilidir. Bu retrospektif analizde, katılımcı sayısı yüksek çalışma grubunda biz 25-OH vitamin D düzeyleri açısından kronik telogen effluvium hastaları ile kontrol grubunu karşılaştırıp değerlendirmeyi amaçladık. Gereç ve Yöntemler: İki yüz doksan bir kronik telogen effluvium hastası ve 258 sağlıklı bireyin serum 25-OH vitamin D seviyeleri retrospektif olarak değerlendirildi ve birbiriyle karşılaştırıldı. Bulgular: Kronik telogen effluvium hasta grubunun serum 25-OH vitamin D düzeyleri sağlıklı kontrol grubu ile karşılaştırıldığında hasta grubunda kontrol grubuna gore istatiksel olarak anlamlı oranda düşük serum 25-OH vitamin D seviyeleri gözlendi (p<0,001). Vitamin D eksikliğinin kronik telogen effluvium hasta grubundaki prevalansı %82.1 idi. Sonuç: Çalışma bulgularına göre, kronik telogen effluvium hastalarında serum 25-OH vitamin D düzeylerinin rutin olarak değerlendirilebileceğini, bu hastalarda vitamin D takviyesinin tedavi seçeneği olarak düşünülebileceğini ileri sürmekteyiz.

Anahtar Kelimeler: Vitamin D; telogen effluvium vitamin D eksikliği; saç hastalığı
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