Journal of Literature Pharmacy Sciences

Essential Oil Plants Traditionally Used in Wound Treatment: Systematic Review
Geleneksel Olarak Yara Tedavisinde Kullanılan Uçucu Yağ Bitkileri: Sistematik Derleme
Melike TEPEa , Esra Zeynep HELVACIb , Ayşe Esra KARADAĞb
aGebze Technical University Faculty of Science, Department of Molecular Biology and Genetics, Kocaeli, Türkiye
bİstanbul Medipol University Faculty of Pharmacy, Department of Pharmacognosy, İstanbul, Türkiye
J Lit Pharm Sci. 2024;13(1):8-17
doi: 10.5336/pharmsci.2022-95011
Article Language: EN
Full Text
ABSTRACT
 Medicinal and aromatic plants such as Artemisia judaica L.., Boswellia papyrifera (Caill. Ex Delile) Hochst., Calendula officinalis L., Centella asiatica (L.) Urb., Lavandula officinalis Chaix, Mentha x piperita L., Syzygium aromaticum (L.) Merr. & L.M. Perry were used as treatment for some basic wounds for 6000 years. These plants were utilized by pounding in a mortar, melting with heat, or using with olive oil. On the other hand, these medicinal and aromatic plants are investigated for their wound-healing activity for the treatment of some chronic diseases such as diabetes, reflux, cancer, arthritis, stroke, hypertension, and obesity. Nowadays, many essential oils (lavender oil, clove oil, tea tree oil etc.) and extracts of these plants are studied treatment of diseases, especially skin diseases such as acne, urticaria, psoriasis, vitiligo, rosacea, atopic dermatitis, and wounds (puncture, surgical, incisions, thermal, chemical or electric burns, bites and stings). This review is a non-meta-analysis review, and it is aimed to provide information about medicinal and aromatic plants that carry important essential oils to share information not only about essential oils but also about the important main components in these oils, and to share some in vitro and in vivo relationships with the wound healing activities of these essential oils. In addition, wound healing studies with volatile components are also briefly mentioned. Plant names are listed in alphabetical order and briefly mentioned about the studies.

Keywords: Essential oil; aromatic plants; natural products; herbal drug
ÖZET
 Artemisia judaica L.., Boswellia papyrifera (Caill. Ex Delile) Hochst., Calendula officinalis L., Centella asiatica (L.) Urb., Lavandula officinalis Chaix, Mentha x piperita L., Syzygium aromaticum (L.) Merr. & L.M. Perry gibi tıbbi ve aromatik bitkiler yaklaşık 6000 yıldır anatomik ve fizyolojik olarak canlı doku bütünlüğünün bozulması olarak bilinen yaraların tedavisinde kullanılmaktadır. Bu tıbbi ve aromatik bitkiler havanda dövülerek, ısı yardımı ile eritilerek veya zeytinyağı ile birlikte bu yaraların tedavisinde kullanılmıştır. Öte yandan diyabet, reflü, kanser, artrit, inme, hipertansiyon ve obezite gibi bazı kronik hastalıkları tedavi etmek için bu bitkilerin yara iyileştirici etkinliği araştırılmıştır. Günümüzde pek çok uçucu yağ (lavanta yağı, karanfil yağı, çay ağacı yağı vb.) ve ekstreler bazı cilt hastalıklarının, özellikle akne, ürtiker, sedef hastalığı, vitiligo, rozasea, atopik dermatit gibi rahatsızlıkların ve yaraların (ponksiyon, cerrahi kesikler, termal, kimyasal veya elektrik yanıkları, ısırıklar ve sokmalar) tedavisi için çalışılmıştır. Bu derleme metaanaliz içermeyen bir derleme olup, önemli uçucu yağlar taşıyan tıbbi ve aromatik bitkiler hakkında bilgi verilmesi, sadece uçucu yağlar değil ayrıca bu yağlarda bulunan önemli başlıca bileşenler hakkında bilgi paylaşılması ve bu uçucu yağların yara iyileştirme aktiviteleriyle ilişkili bazı in vitro ve in vivo araştırmalar hakkında açıklama yapılması amaçlanmıştır. Ayrıca kısaca uçucu bileşenlerle yapılan yara iyi edici çalışmalardan da bahsedilmiştir. Bitki adları alfabetik olacak şekilde sıralanmış ve yapılan çalışmalardan kısaca bahsedilerek açıklanmıştır.

Anahtar Kelimeler: Uçucu yağlar; aromatik bitkiler; doğal ürünler; bitkisel ilaçlar
REFERENCES:
  1. Barrett B, Kiefer D, Rabago D. Assessing the risks and benefits of herbal medicine: an overview of scientific evidence. Altern Ther Health Med. 1999;5(4):40-9. [PubMed] 
  2. Ait Elallem K, Sobeh M, Boularbah A, Yasri A. Chemically degraded soil rehabilitation process using medicinal and aromatic plants: review. Environ Sci Pollut Res Int. 2021;28(1):73-93. [Crossref]  [PubMed] 
  3. Yeşilada E, Honda G, Sezik E, Tabata M, Goto K, Ikeshiro Y. Traditional medicine in Turkey. IV. Folk medicine in the Mediterranean subdivision. J Ethnopharmacol. 1993;39(1):31-8. [Crossref]  [PubMed] 
  4. Altundag E, Ozturk M. Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia-Soc Behav Sci. 2011;19:756-77. [Crossref] 
  5. Nićiforović N, Mihailović V, Masković P, Solujić S, Stojković A, Pavlović Muratspahić D. Antioxidant activity of selected plant species; potential new sources of natural antioxidants. Food Chem Toxicol. 2010;48(11):3125-30. [Crossref]  [PubMed] 
  6. Tatlı İ. Doğal aromaterapötik yağlar ile cilt terapisi [Skin therapy with natural aromatherapeutic oils]. Tur Klin J Cosmet Dermatol. 2012;5(4):46-54. [Link] 
  7. Mohebitabar S, Shirazi M, Bioos S, Rahimi R, Malekshahi F, Nejatbakhsh F. Therapeutic efficacy of rose oil: a comprehensive review of clinical evidence. Avicenna J Phytomed. 2017;7(3):206-13. [PubMed]  [PMC] 
  8. Maruyama N, Sekimoto Y, Ishibashi H, Inouye S, Oshima H, Yamaguchi H, et al. Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil. J Inflamm (Lond). 2005;2(1):1. [Crossref]  [PubMed]  [PMC] 
  9. Mahboubi M, Kashani LM. The anti-dermatophyte activity of Commiphora molmol. Pharm Biol. 2016;54(4):720-5. [Crossref]  [PubMed] 
  10. Lee SH, Heo Y, Kim YC. Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice. J Vet Sci. 2010;11(1):35-41. [Crossref]  [PubMed]  [PMC] 
  11. Manzuoerh R, Farahpour MR, Oryan A, Sonboli A. Effectiveness of topical administration of Anethum graveolens essential oil on MRSA-infected wounds. Biomed Pharmacother. 2019;109:1650-8. [Crossref]  [PubMed] 
  12. Mohammed HA, Qureshi KA, Ali HM, Al-Omar MS, Khan O, Mohammed SAA. Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as part of the plant's use in traditional medicine; phytochemical, antioxidant, anti-inflammatory, and antibiofilm properties of the plant's essential oils. Antioxidants (Basel). 2022;11(2):332. [Crossref]  [PubMed]  [PMC] 
  13. Msaada K, Salem N, Bachrouch O, Bousselmi S, Tammar S, Alfaify A, et al. Chemical composition and antioxidant and antimicrobial activities of wormwood (Artemisia absinthium L.) essential oils and phenolics. J Chem. 2015;2015. [Crossref] 
  14. Agwa MM, Sabra S, Atwa NA, Dahdooh HA, Lithy RM, Elmotasem H. Potential of frankincense essential oil-loaded whey protein nanoparticles embedded in frankincense resin as a wound healing film based on green technology. J Drug Deliv Sci Technol. 2022;71:103291. [Crossref] 
  15. Narayanankutty A, Kunnath K, Alfarhan A, Rajagopal R, Ramesh V. Chemical composition of Cinnamomum verum leaf and flower essential oils and analysis of their antibacterial, insecticidal, and larvicidal properties. Molecules. 2021;26(20):6303. [Crossref]  [PubMed]  [PMC] 
  16. Ximenes RM, de Morais Nogueira L, Cassundé NM, Jorge RJ, dos Santos SM, Magalhães LP, et al. Antinociceptive and wound healing activities of Croton adamantinus Müll. Arg. essential oil. J Nat Med. 2013;67(4):758-64. [Crossref]  [PubMed] 
  17. Almas I, Innocent E, Machumi F, Kisinza W. Chemical composition of essential oils from Eucalyptus globulus and Eucalyptus maculata grown in Tanzania. Scientific African. 2021;12:e00758. [Crossref] 
  18. Miguel MG, Cruz C, Faleiro L, Simões MT, Figueiredo AC, Barroso JG, et al. Foeniculum vulgare essential oils: chemical composition, antioxidant and antimicrobial activities. Nat Prod Commun. 2010;5(2):319-28. [Crossref]  [PubMed] 
  19. Andjić M, Božin B, Draginić N, Kočović A, Jeremić JN, Tomović M, et al. Formulation and evaluation of Helichrysum italicum essential oil-based topical formulations for wound healing in diabetic rats. Pharmaceuticals (Basel). 2021;14(8):813. [Crossref]  [PubMed]  [PMC] 
  20. Agarwal S, Prakash R. Essential oil composition of solvent extract of Hibiscus rosasinensis flower. Orient J Chem. 2013;29(2):813-4. [Crossref] 
  21. Schepetkin IA, Özek G, Özek T, Kirpotina LN, Khlebnikov AI, Quinn MT. Chemical composition and immunomodulatory activity of essential oils from Rhododendron albiflorum. Molecules. 2021;26(12):3652. [Crossref]  [PubMed]  [PMC] 
  22. El-Sayed SM, Hassan KM, Abdelhamid AN, Yousef EE, Abdellatif YMR, Abu-Hussien SH, et al. Exogenous paclobutrazol reinforces the antioxidant and antimicrobial properties of lavender (Lavandula officinalis L.) oil through modulating its composition of oxygenated terpenes. Plants (Basel). 2022;11(12):1607. [Crossref]  [PubMed]  [PMC] 
  23. Labib RM, Ayoub IM, Michel HE, Mehanny M, Kamil V, Hany M, et al. Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations. PLoS One. 2019;14(9):e0219561. [Crossref]  [PubMed]  [PMC] 
  24. Zarezadeh S, Riahi H, Shariatmadari Z, Sonboli A. Effects of cyanobacterial suspensions as bio-fertilizers on growth factors and the essential oil composition of chamomile, Matricaria chamomilla L. J Appl Phycol. Journal of Applied Phycology. 2020;32(2):1231-41. [Crossref] 
  25. Camele I, Gruľová D, Elshafie HS. Chemical composition and antimicrobial properties of Mentha × piperita cv. 'Kristinka' Essential Oil. Plants (Basel). 2021;10(8):1567. [Crossref]  [PubMed]  [PMC] 
  26. Topuz E, Madanlar N, Erler F. Chemical composition, toxic and development- and reproduction-inhibiting effects of some essential oils against Tetranychus urticae Koch (Acarina: Tetranychidae) as fumigants. J Plant Dis Prot. 2018;125(4):377-87. [Crossref] 
  27. Mansour RB, Beji RS, Wasli H, Zekri S, Ksouri R, Megdiche-Ksouri W, et al. Gastroprotective effect of microencapsulated Myrtus communis essential oil against Ethanol/HCl-induced acute gastric lesions. Molecules. 2022;27(5):1566. [Crossref]  [PubMed]  [PMC] 
  28. Mohr FB, Lermen C, Gazim ZC, Gonçalves JE, Alberton O. Antifungal activity, yield, and composition of Ocimum gratissimum essential oil. Genet Mol Res. 2017;16(1). [Crossref]  [PubMed] 
  29. Avola R, Granata G, Geraci C, Napoli E, Graziano ACE, Cardile V. Oregano (Origanum vulgare L.) essential oil provides anti-inflammatory activity and facilitates wound healing in a human keratinocytes cell model. Food Chem Toxicol. 2020;144:111586. [Crossref]  [PubMed] 
  30. Jaradat N, Hawash M, Qadi M, Abualhasan M, Odetallah A, Qasim G, et al. Chemical markers and pharmacological characters of Pelargonium graveolens essential oil from palestine. Molecules. 2022;27(17):5721. [Crossref]  [PubMed]  [PMC] 
  31. Tümen İ, Akkol EK, Taştan H, Süntar I, Kurtca M. Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait). J Ethnopharmacol. 2018;211:235-46. [Crossref]  [PubMed] 
  32. de Almeida JM, Crippa BL, Martins Alencar de Souza VV, Perez Alonso VP, da Motta Santos Júnior E, Siqueira Franco Picone C, et al. Antimicrobial action of oregano, thyme, clove, cinnamon and black pepper essential oils free and encapsulated against foodborne pathogens. Food Control. 2023;144. [Crossref] 
  33. Boudjelal A, Napoli E, Benkhaled A, Benazi L, Bey R, Gentile D, et al. In vivo wound healing effect of Italian and Algerian Pistacia vera L. resins. Fitoterapia. 2022;159:105197. [Crossref]  [PubMed] 
  34. Limem-Ben Amor I, Boubaker J, Ben Sgaier M, Skandrani I, Bhouri W, Neffati A, et al. Phytochemistry and biological activities of Phlomis species. J Ethnopharmacol. 2009;125(2):183-202. [Crossref]  [PubMed] 
  35. Gao Z, Yu Z, Qiao Y, Bai L, Song X, Shi Y, et al. Chemical profiles and enzyme-targeting acaricidal properties of essential oils from Syzygium aromaticum, Ilex chinensis and Citrus limon against Haemaphysalis longicornis (Acari: Ixodidae). Ind Crops Prod. 2022;188(PA):115697. [Crossref] 
  36. Scanavacca J, Iecher Faria MG, Canonico Silva GC, Inumaro RS, Gonçalves JE, Kupski L, et al. Chemical analysis, antifungal and antimycotoxigenic activity of tetradenia riparia essential oil and crude extract. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022;39(7):1296-310. [Crossref]  [PubMed] 
  37. Zare MR, Khorram M, Barzegar S, Asadian F, Zareshahrabadi Z, Saharkhiz MJ, et al. Antimicrobial core-shell electrospun nanofibers containing Ajwain essential oil for accelerating infected wound healing. Int J Pharm. 2021;603:120698. [Crossref]  [PubMed] 
  38. Salas-Oropeza J, Jimenez-Estrada M, Perez-Torres A, Castell-Rodriguez AE, Becerril-Millan R, Rodriguez-Monroy MA, et al. Wound healing activity of the essential oil of Bursera morelensis, in mice. Molecules. 2020;25(8):1795. [Crossref]  [PubMed]  [PMC] 
  39. Seyed Ahmadi SG, Farahpour MR, Hamishehkar H. Topical application of Cinnamon verum essential oil accelerates infected wound healing process by increasing tissue antioxidant capacity and keratin biosynthesis. Kaohsiung J Med Sci. 2019;35(11):686-94. [Crossref]  [PubMed] 
  40. Ishfaq M, Akhtar B, Muhammad F, Sharif A, Akhtar MF, Hamid I, et al. Antioxidant and wound healing potential of essential oil from citrus reticulata peel and its chemical characterization. Curr Pharm Biotechnol. 2021;22(8):1114-21. [Crossref]  [PubMed] 
  41. Chandorkar N, Tambe S, Amin P, Madankar C. A systematic and comprehensive review on current understanding of the pharmacological actions, molecular mechanisms, and clinical implications of the genus Eucalyptus. Phytomed Plus. 2021;1(4):100089. [Crossref] 
  42. Kubera Sampath Kumar S, Prakash C, Ramesh P, Sukumar N, Balaji J, Palaniswamy NK. Study of Wound Dressing Material Coated with Natural Extracts of Calotropis Gigantean, Eucalyptus Globulus and Buds of Syzygium Aromaticum Solution Enhanced with rhEGF (REGEN-DTM 60). J Nat Fibers. 2021;18 (12):2270-83. [Crossref] 
  43. Mazutti da Silva SM, Rezende Costa CR, Martins Gelfuso G, Silva Guerra EN, de Medeiros Nóbrega YK, Gomes SM, et al. Wound healing effect of essential oil extracted from Eugenia dysenterica DC (Myrtaceae) leaves. Molecules. 2018;24(1):2. [Crossref]  [PubMed]  [PMC] 
  44. Keskin I, Gunal Y, Ayla S, Kolbasi B, Sakul A, Kilic U, et al. Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing. Biotech Histochem. 2017;92(4):274-82. [Crossref]  [PubMed] 
  45. Andjić M, Draginić N, Kočović A, Jeremić J, Vučićević K, Jeremić N, et al. Immortelle essential oil-based ointment improves wound healing in a diabetic rat model. Biomed Pharmacother. 2022;150:112941. [Crossref]  [PubMed] 
  46. Bhaskar A, Nithya V. Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Indian J Pharmacol. 2012;44(6):694-8. [Crossref]  [PubMed]  [PMC] 
  47. Yilmazoğlu E, Hasdemir İM, Hasdemir B. Recent studies on antioxidant, antimicrobial and ethnobotanical uses of hypericum perforatum L. (Hypericaceae). J Turkish Chem Soc Sect A Chem. 2022;9(2):373-94. [Crossref] 
  48. Grafakou ME, Barda C, Karikas GA, Skaltsa H. Hypericum essential oils-composition and bioactivities: an update (2012-2022). Molecules. 2022;27(16):5246. [Crossref]  [PubMed]  [PMC] 
  49. Mori HM, Kawanami H, Kawahata H, Aoki M. Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model. BMC Complement Altern Med. 2016;16:144. [Crossref]  [PubMed]  [PMC] 
  50. Boukhatem MN, Chader H, Houche A, Oudjida F, Benkebaili F, Hakim Y. Topical Emulsion containing Lavandula stoechas essential oil as a therapeutic agent for cutaneous wound healing. J. 2021;4(3):288-307. [Crossref] 
  51. Lusby PE, Coombes AL, Wilkinson JM. A comparison of wound healing following treatment with Lavandula x allardii honey or essential oil. Phytother Res. 2006;20(9):755-7. [Crossref]  [PubMed] 
  52. Ben Djemaa FG, Bellassoued K, Zouari S, El Feki A, Ammar E. Antioxidant and wound healing activity of Lavandula aspic L. ointment. J Tissue Viability. 2016;25(4):193-200. [Crossref]  [PubMed] 
  53. Yuca H, Karakaya S. Matricaria chamomilla L. In: Gürağaç Dereli FT, Ilhan M, Belwal T, eds. Novel Drug Targets with Traditional Herbal Medicines. 1st ed. Copenhagen: Springer; 2022. p.387-400. [Crossref] 
  54. European medicines agency. Herbal medicine: summary for the public Matricaria flower Matricaria recutita L., flos 2015. Available from: www.ema.europa.eu/contact (Cited: 11.11.2023) [Link] 
  55. de Assis KMA, da Silva Leite JM, de Melo DF, Borges JC, Santana LMB, Dos Reis MML, et al. Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing. Drug Deliv Transl Res. 2020;10(6):1748-63. [Crossref]  [PubMed] 
  56. Mahendran G, Rahman LU. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)-A review. Phytother Res. 2020;34(9):2088-139. [Crossref]  [PubMed] 
  57. Modarresi M, Farahpour MR, Baradaran B. Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model. Inflammopharmacology. 2019;27(3):531-7. [Crossref]  [PubMed] 
  58. Teixidor-Toneu I, Martin GJ, Ouhammou A, Puri RK, Hawkins JA. An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco. J Ethnopharmacol. 2016;188:96-110. [Crossref]  [PubMed] 
  59. Khezri K, Farahpour MR, Mounesi Rad S. Efficacy of Mentha pulegium essential oil encapsulated into nanostructured lipid carriers as an in vitro antibacterial and infected wound healing agent. Colloids Surfaces A Physicochem Eng Asp. 2020;589:124414. [Crossref] 
  60. Raeiszadeh M, Esmaeili-Tarzi M, Bahrampour-Juybari K, Nematollahi-mahani SN, Pardakhty A, Nematollahi MH, et al. Evaluation the effect of Myrtus communis L. extract on several underlying mechanisms involved in wound healing: an in vitro study. South African J Bot. 2018;118:144-50. [Crossref] 
  61. Orafidiya LO, Agbani EO, Abereoje OA, Awe T, Abudu A, Fakoya FA. An investigation into the wound-healing properties of essential oil of Ocimum gratissimum linn. J Wound Care. 2003;12(9):331-4. [Crossref]  [PubMed] 
  62. Bora L, Avram S, Pavel IZ, Muntean D, Liga S, Buda V, et al. An Up-to-date review regarding cutaneous benefits of Origanum vulgare L. essential oil. Antibiotics (Basel). 2022;11(5):549. [Crossref]  [PubMed]  [PMC] 
  63. Asgarirad H, Tehrani BB, Azad Bakht M, Ebrahimnejad P, Farmoudeh A, Davoodi A, et al. Wound healing properties of Pelargonium Graveolens L'Hér extract lipogel: In-Vivo evaluation in an animal burn model. Curr Drug Deliv. 2023;20(5):601-7. [Crossref]  [PubMed] 
  64. Mahboubi M, Feizabadi MM, Khamechian T, Kazempour N, Razavi Zadeh M, Sasani F, et al. The effect of Oliveria Decumbens and Pelargonium Graveolens on healing of infected skin wounds in mice. World J Plast Surg. 2016;5(3):259-64. [PubMed]  [PMC] 
  65. Yudiyanto, Hakim N, Wakhidah AZ. Ethnobotany of medicinal plants from Lampung Tribe around Way Kambas National Park , Indonesia. Nusant Biosci. 2022;14(1):84-94. [Crossref] 
  66. Han X, Beaumont C, Rodriguez D, Bahr T. Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells. Phytother Res. 2018;32(9):1848-52. [Crossref]  [PubMed] 
  67. Zineb M, Djerrou Z, Habibatni S, Riachi F, Djaalab H, Pacha YH. Physicochemical characteristics and sub chronic oral toxicity of Pistacia lentiscus L. vegetable oil in rabbits. J Biol Sci. 2016;16(1):43-8. [Crossref] 
  68. Djerrou Z, Djaalab H, Riachi F, Serakta M, Chettoum A, Maameri Z, et al. Irritantcy potential and sub acute dermal toxicity study of Pistacia lentiscus fatty oil as a topical traditional remedy. Afr J Tradit Complement Altern Med. 2013;10(3):480-9. [Crossref]  [PubMed]  [PMC] 
  69. Abdeldjelil MC, Bensegueni A, Messaï A, Agabou A, Benazzouz H. Medicinal use of Pistacia lentiscus fixed oil in Constantine province, north-east Algeria. J Nat Prod Plant Resour. 2014;4(1):48-51. [Link] 
  70. Okur ME, Karadağ AE, Özhan Y, Sipahi H, Ayla Ş, Daylan B, et al. Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract. J Ethnopharmacol. 2021;266:113408. [Crossref]  [PubMed] 
  71. Okur ME, Karadağ AE, Üstündağ Okur N, Özhan Y, Sipahi H, Ayla Ş, et al. In vivo wound healing and in vitro anti-inflammatory activity evaluation of Phlomis russeliana extract gel formulations. Molecules. 2020;25(11):2695. [Crossref]  [PubMed]  [PMC] 
  72. Farahpour MR, Pirkhezr E, Ashrafian A, Sonboli A. Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model. Biomed Pharmacother. 2020;128:110120. [Crossref]  [PubMed] 
  73. Zougagh S, Belghiti A, Rochd T, Zerdani I, Mouslim J. Medicinal and aromatic plants used in traditional treatment of the oral pathology: the ethnobotanical survey in the economic capital Casablanca, Morocco (North Africa). Nat Prod Bioprospect. 2019;9(1):35-48. [Crossref]  [PubMed]  [PMC] 
  74. Alam P, Ansari MJ, Anwer MK, Raish M, Kamal YK, Shakeel F. Wound healing effects of nanoemulsion containing clove essential oil. Artif Cells Nanomed Biotechnol. 2017;45(3):591-7. [Crossref]  [PubMed] 
  75. Ghuman S, Ncube B, Finnie JF, McGaw LJ, Mfotie Njoya E, Coopoosamy RM, et al. Antioxidant, anti-inflammatory and wound healing properties of medicinal plant extracts used to treat wounds and dermatological disorders. South African J Bot. 2019;126:232-40. [Crossref] 

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1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com