Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Erkek İnfertilitesinde Koenzim Q10
Coenzyme Q10 in Male Infertility
Ayçıl ÖZTURAN ŞİRİNa, Yasemin AKDEVELİOĞLUb
aDepartment of Nutrition and Dietetics, Adnan Menderes University Faculty of Health Sciences, Aydın, TURKEY
bDepartment of Nutrition and Dietetics, Gazi University Faculty of Health Sciences, Ankara, TURKEY
Turkiye Klinikleri J Health Sci. 2021;6(1):139-47
doi: 10.5336/healthsci.2020-75062
Article Language: EN
Full Text
ABSTRACT
 Currently the male factor is frequently encountered in the infertility problem. Basically, the factors that cause sperm dysfunction and male infertility are environmental, physiological and genetic. Excessive amount of reactive oxygen species and other oxidant radicals have been associated with male infertility. In addition, although semen analysis parameters appear normal in idiopathic male infertility, it is suggested that the possible cause of infertility is oxidative stress. Antioxidants in foods that are protective against oxidative stress increase the success of assisted reproductive techniques by protecting spermatozoa from free oxygen radicals, preventing DNA breaks caused by free oxygen radicals, and supporting the sperm maturation process. Coenzyme Q10 (CoQ10), which is found in every cell and has the ability to dissolve in oil, is a vitamin-like compound that acts as a coenzyme in key enzymatic reactions in energy production in the cell. Endogenous CoQ10, is significantly associated with sperm count and motility and is shown as one of the most important antioxidants in seminal plasma. Exogenous CoQ10 administration can be explained by its positive effects on sperm motility, its effectiveness in mitochondria and its antioxidant effects. In this review, articles investigating the effect of oxidative stress on infertility and the role of CoQ10, a natural antioxidant vitamin in the treatment of infertility, were presented. As a result, the positive effects of using CoQ10 as a supportive treatment in male infertility have been shown in studies. However, more comprehensive, long-term and pregnancy-related studies are needed.

Keywords: İnfertilite; koenzim Q10; oksidatif stress
ÖZET
 Günümüzde infertilite problemi içerisinde erkek faktörü sıklıkla karşımıza çıkmaktadır. Temel olarak sperm fonksiyon bozukluğu ve erkek infertilitesine neden olan faktörler çevresel, fizyolojik ve genetiktir. Aşırı miktarda bulunan reaktif oksijen türü ve diğer oksidan radikaller erkek infertilitesi ile ilişkilendirilmiştir. Ayrıca idiyopatik erkek infertilitesinde semen analizi parametreleri normal görünmesine rağmen olası infertilite nedeninin oksidatif stres olduğu öne sürülmektedir. Besinlerde bulunan ve oksidatif strese karşı koruyucu olan antioksidanlar spermatozoayı serbest oksijen radikallerinden koruyarak, serbest oksijen radikallerinin neden olduğu DNA kırılmalarını önleyerek, sperm olgunlaşma sürecine destek vererek yardımcı üreme tekniklerinin başarısını artırmaktadır. Her hücrede bulunan ve yağda çözünebilme özelliğine sahip olan koenzim Q10 (CoQ10), hücrede enerji üretiminde kilit enzimatik reaksiyonlarda koenzim olarak görev yapan vitamin benzeri bir bileşiktir. Endojen CoQ10 sperm sayısı ve hareketliliği ile önemli ölçüde ilişkili olup, seminal plazmada en önemli antioksidanlardan biri olarak gösterilmektedir. Eksojen CoQ10 uygulamasının sperm hareketliliği üzerine olumlu etkilerinin olması, mitokondrideki etkinliği ve antioksidan etkileri ile açıklanabilmektedir. Bu derlemede, oksidatif stresin infertilite üzerindeki etkisini ve infertilite tedavisinde doğal bir antioksidan vitamin olan CoQ10'in rolünü araştıran makaleler incelenmiştir. Sonuç olarak, yapılan çalışmalarda genel olarak CoQ10'in destekleyici bir tedavi olarak erkek infertilitesinde kullanımının olumlu etkileri gösterilmiştir. Ancak, daha kapsamlı, uzun süreli ve gebelikle ilgili sonuçların da değerlendirildiği çalışmaların yapılmasına ihtiyaç duyulmaktadır.

Anahtar Kelimeler: Infertility; coenzyme Q10; oxidative stress
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www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com