Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Efficacy of Dexpanthenol/Sodium Hyaluronate Fixed Combination Versus Sodium Hyaluronate Eye Drops for theTreatment of Dry Eye Disease and Ocular Surface Inflammation Following Cataract Surgery: A Comparative Study
Katarakt Cerrahisi Sonrası Oküler Yüzey İnflamasyonu ve Kuru Göz Hastalığı Tedavisinde Dekspantenol/Sodyum Hyaluronat Fiks Kombinasyonuna Karşı Sodyum Hyaluronat Damla Etkinliği: Karşılaştırmalı Çalışma
Huri SABURa , Mutlu ACARa , Neşe ARSLANa
aSağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Göz Kliniği, Ankara, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(2):81-9
doi: 10.5336/ophthal.2022-93385
Article Language: EN
Full Text
ABSTRACT
 Objective: To compare the efficacy of dexpanthenol/ sodium hyaluronate fixed combination with sodium hyaluronate eye drops in the treatment of dry eye disease (DED) and ocular surface inflammation (OSI) following cataract surgery. Material and Methods: Sixty-three patients who underwent cataract surgery were included in this study. In addition to the standard postoperative treatment, one group (study group, n=30 eyes) received dexpanthenol/sodium hyaluronate fixed combination eye drops, while the other group was given sodium hyaluronate eye drops (control group, n=33 eyes). The 2 groups were compared in terms of best-corrected visual acuity, tear break-up time (TBUT), corneal flourescein staining, ocular surface disease index (OSDI) and in vivo confocal microscopy (IVCM) findings. Results: While TBUT was significantly greater in the study group than the control group (11.2, 8.9, respectively), corneal floresein staining (0.13, 0.48, respectively) and OSDI (10.8, 17.1, respectively) were significantly lower in the study group compared to the control group at postoperative 4 months. In IVCM, the number of dendritic cells and activated keratocytes were significantly lower in the study group (40.8, 13.9 respectively) compared to the control group (51.2, 18.0, respectively). In addition, while the total number of nerves in the study group (4.57) was higher than that of the control group (3.91), the nerve tortuosity was lower in the study group (1.57, 2.18, respectively). Conclusion: Dexpanthenol/sodium hyaluronate fixed combination eye drops could be preferred as an adjuvant for the treatment of DED and OSI following cataract surgery.

Keywords: Cataract surgery; dry eye disease; dexpanthenol/sodium hyaluronate fixed combination; in vivo confocal microscopy; ocular surface inflammation
ÖZET
 Amaç: Katarakt cerrahisi sonrası kuru göz hastalığı (KGH) ve oküler yüzey inflamasyonu (OYİ) tedavisinde dekspantenol/sodyum hyaluronat fiks kombinasyon etkinliğini, sodyum hyaluronat göz damlası ile karşılaştırmaktır. Gereç ve Yöntemler: Çalışmaya, katarakt cerrahisi uygulanan 63 hasta dâhil edildi. Standart postoperatif tedaviye ek olarak, bir gruba (çalışma grubu, n=30 göz) dekspantenol/sodyum hyaluronat fiks kombinasyon göz damlası, diğer gruba ise sodyum hyaluronat göz damlası (kontrol grubu, n=33 göz) verildi. İki grup, en iyi düzeltilmiş görme keskinliği (EİDGK), gözyaşı kırılma zamanı (GKZ), fluoresein ile korneal boyanma, oküler yüzey hastalığı indeksi (OYHİ) ve in vivo konfokal mikroskopi (IVKM) bulguları açısından karşılaştırıldı. Bulgular: Ameliyat sonrası 4. ayda GKZ çalışma grubunda kontrol grubuna göre (11,2-8,9, sırasıyla) anlamlı olarak daha yüksek iken, fluoresein ile korneal boyanma (0,13-0,48, sırasıyla) ve OYHİ (10,8-17,1, sırasıyla) çalışma grubunda kontrol grubuna göre anlamlı derecede düşüktü. IVKM'de dendritik hücre ve aktive keratosit sayısı, çalışma grubunda (40,8-13,9, sırasıyla) kontrol grubuna göre (51,2-18,0, sırasıyla) daha düşük saptandı. Ayrıca çalışma grubunda sinir sayısı (4,57) kontrol grubuna göre (3,91) daha yüksek iken, sinir kıvrımlanması çalışma grubunda (1,57-2,18, sırasıyla) daha azdı. Sonuç: Dekspantenol/sodyum hyaluronat fiks kombinasyon göz damlası, katarakt cerrahisi sonrası KGH ve OYİ tedavisinde yardımcı ajan olarak tercih edilebilir.

Anahtar Kelimeler: Katarakt cerrahisi; kuru göz hastalığı; dekspantenol/sodyum hyaluronat fiks kombinasyonu; in vivo konfokal mikroskopi; oküler yüzey inflamasyonu
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