Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Effects of Single-Dose Preemptive Intravenous Dexketoprofen Trometamol and Ibuprofen on Pain and Edema Control Following Third Molar Surgery: A Prospective, Randomized, Double-Blind and Clinical Study
Tek Doz Preemptif İntravenöz Deksketoprofen Trometamol ve İbuprofen'in Üçüncü Molar Cerrahisi Sonrası Ağrı ve Ödem Kontrolü Üzerine Etkileri: Prospektif, Randomize, Çift Kör ve Klinik Bir Çalışma
Suheyb BİLGEa, Mustafa KARAKAYAb, Ebru BAYDANa, Ahmet Emin DEMİRBAŞa
aDepartment of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Kayseri, Türkiye
bClinic of Oral and Maxillofacial Surgery, Sultanbeyli Oral and Dental Health Hospital, İstanbul, Türkiye
Turkiye Klinikleri J Dental Sci. 2022;28(3):502-10
doi: 10.5336/dentalsci.2021-86763
Article Language: EN
Full Text
ABSTRACT
 Objective: This comparative study aims to investigate the single-dose preemptive effects of intravenous (IV) dexketoprofen trometamol, ibuprofen for pain and edema control in mandibular wisdom teeth surgery. Material and Methods: In this study, 75 patients were randomly divided into 3 groups. Group 1 received IV ibuprofen 60 min before surgery; Group 2 received IV dexketoprofen trometamol 60 min before surgery; Group 3 received IV placebo (100 cc saline) 60 min before surgery. The pain and facial swelling were evaluated. Postoperative pain was recorded with a Visual Analog Scale (VAS) during 24 h. The total recovery acetaminophen intake dose was recorded in the first 24 h. Also, a 3D surface imaging device was used in the evaluation of swelling. Results: There was no statistically significant difference in the pain between the ibuprofen and dexketoprofen groups. There was a statistically significant difference in the edema on the 2nd day (T1) between the ibuprofen and dexketoprofen group (p=0.010). On the 2nd day edema, the amount of edema observed in the ibuprofen group was recorded as the least. Postoperative edema and pain were higher in the placebo group than in the other groups (p<0.05). Conclusion: The findings obtained in this study suggest that the preemptive application of IV ibuprofen and dexketoprofen is effective in the control of edema and pain compared to the placebo group after third molar surgery.

Keywords: Pain management; facial pain; analgesic; preemptive analgesia; oral surgery
ÖZET
 Amaç: Bu karşılaştırmalı çalışma, mandibular gömülü yirmi yaş dişlerin cerrahi çekimlerinde intravenöz (IV) deksketoprofen trometamol ile IV ibuprofenin ağrı ve ödem kontrolünde preemptif kullanımlarının etkilerini araştırmayı amaçlamaktadır. Gereç ve Yöntemler: Bu çalışmada, 75 hasta rastgele olacak şekilde 3 gruba ayrıldı. Grup 1 ameliyattan 60 dakika önce IV ibuprofen aldı; Grup 2 ameliyattan 60 dakika önce IV deksketoprofen trometamol aldı; Grup 3, ameliyattan 60 dakika önce IV plasebo (100 cc salin) aldı. Ağrı ve yüzdeki şişlik değerlendirildi. Postoperatif ağrı 24 saat boyunca Vizüel Analog Skala (VAS) ile kaydedildi. İlk 24 saatlik dönemde toplam asetaminofen alım dozu kaydedildi. Ayrıca ödemin değerlendirilmesinde 3 boyutlu yüzey görüntüleme cihazı kullanıldı. Bulgular: İbuprofen ve deksketoprofen grupları arasında ağrı kontrolü açısından istatistiksel olarak anlamlı fark bulunamadı. Ödem kontrolünde ise operasyon sonrası 2. günde (T1) ibuprofen ve deksketoprofen grupları arasında istatistiksel olarak anlamlı fark tespit edildi (p=0,010). İkinci gün ödem kontrolünde ibuprofen grubunda gözlenen ödem miktarı en az olarak kaydedildi. Plasebo grubunda ise postoperatif ödem ve ağrı değerlerinin diğer gruplara göre daha yüksek olduğu tespit edildi (p<0,05). Sonuç: Bu çalışmada elde edilen bulgular, 3. molar cerrahisi sonrası plasebo grubuna kıyasla IV ibuprofen ve deksketoprofenin preemptif uygulanmasının ödem ve ağrı kontrolünde etkili olduğunu düşündürmektedir.

Anahtar Kelimeler: Ağrı yönetimi; yüz ağrısı; analjezi; önleyici analjezi; oral cerrahi
REFERENCES:
  1. Salmen FS, Oliveira MR, Gabrielli MAC, Piveta ACG, Pereira-Filho VA, Gabriell MFR. Third molar extractions: a retrospective study of 1178 cases. RGO-Revista Gaúcha Odontol. 2016;64:250-5. [Crossref] 
  2. Amin MM, Laskin DM. Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars. Oral Surg Oral Med Oral Pathol. 1983;55(5):448-51. [Crossref]  [PubMed] 
  3. Sánchez-Pérez A, Mu-oz-Pe-alver J, Moya-Villaescusa MJ, Sánchez-Matás C. Effects of the preoperative administration of dexketoprofen trometamol on pain and swelling after implant surgery: a randomized, double-blind controlled trial. J Oral Implantol. 2018;44(2):122-9. [Crossref]  [PubMed] 
  4. Lima TC, Bagordakis E, Falci SGM, Dos Santos CRR, Pinheiro MLP. Pre-emptive effect of dexamethasone and diclofenac sodium associated with codeine on pain, swelling, and trismus after third molar surgery: a split-mouth, randomized, triple-blind, controlled clinical trial. J Oral Maxillofac Surg. 2018;76(1):60-6. [Crossref]  [PubMed] 
  5. Kadur SN, Ahmed F, Prohit A, Khandelwal M, Mistry T. The effect of intravenous dexamethasone on postoperative pain, nausea and vomiting after intrathecal pethidine and bupivacaine in lower limb orthopedic surgery. Anaesthesia, Pain Intensive Care. 2015;19(3):254-9. [Link] 
  6. Demirbas AE, Karakaya M, Bilge S, Canpolat DG, Kütük N, Alkan A. Does Single-dose preemptive intravenous ibuprofen reduce postoperative pain after third molar surgery? A prospective, randomized, double-blind clinical study. J Oral Maxillofac Surg. 2019;77(10):1990-7. [Crossref]  [PubMed] 
  7. Naghipour A, Esmaeelinejad M, Dehnad SV, Shahi A, Jarrahi A. Comparison of lidocaine with articaine buccal injection in reducing complications following impacted mandibular third molar surgery: a split-mouth randomized clinical trial. J Dent Anesth Pain Med. 2020;20(4):213-21. [Crossref]  [PubMed]  [PMC] 
  8. Yamaguchi A, Sano K. Effectiveness of preemptive analgesia on postoperative pain following third molar surgery: review of literatures. Jpn Dent Sci Rev. 2013;49(4):131-8. [Crossref] 
  9. Kano K, Kawamura K, Miyake T. Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery: a prospective, single-blind, randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2021;26(1):e64-e70. [Crossref]  [PubMed]  [PMC] 
  10. Viswanath A, Oreadi D, Finkelman M, Klein G, Papageorge M. Does pre-emptive administration of intravenous ibuprofen (caldolor) or intravenous acetaminophen (Ofirmev) Reduce postoperative pain and subsequent narcotic consumption after third molar surgery? J Oral Maxillofac Surg. 2019 ;77(2):262-70. [Crossref]  [PubMed] 
  11. Alan H, Yolcu Ü, Koparal M, Özgür C, Öztürk SA, Malkoç S. Evaluation of the effects of the low-level laser therapy on swelling, pain, and trismus after removal of impacted lower third molar. Head Face Med. 2016;12(1):25. [Crossref]  [PubMed]  [PMC] 
  12. Ramires GAD, de Souza Santos AM, Momesso GAC, Polo TOB, Silva WPP, Barbosa S, et al. Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study. Clin Oral Investig. 2021;25(4):2297-305. [Crossref]  [PubMed] 
  13. Shah R, Mahajan A, Shah N, Dadhania AP. Preemptive analgesia in third molar impaction surgery. Natl J Maxillofac Surg. 2012;3(2):144-7. [Crossref]  [PubMed]  [PMC] 
  14. Srivastava AK, Singh SK, Kumar M, Srivastava A, Pathak PK. Comparative study for effectiveness of preemptive analgesia on postoperative pain and swelling following gingivectomy. IP Int J Periodontol Implantol. 2020;5(1):25-8. [Crossref] 
  15. Kale SG, Shetty A, Moin A, Archana TS, Kumar P, Bagga V. Comparative evaluation of preemptive analgesia of dextromethorphan and ibuprofen in third molar surgeries. Ann Maxillofac Surg. 2020;10(2):312-9. [Crossref]  [PubMed]  [PMC] 
  16. Momesso GAC, Lemos CAA, de Lima VN, Delanora LA, Santiago-Júnior JF, Faverani LP, et al. Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis. Res Soc Dev. 2020;9:e968997979. [Crossref] 
  17. Küpeli İ, Gülnahar Y. Impact of pre-emptive intravenous ibuprofen on perioperative analgesia in patients undergoing third molar extraction: a randomised controlled study. Turk J Anaesthesiol Reanim. 2019;47(6):480-4. [Crossref]  [PubMed]  [PMC] 
  18. Gülnahar Y, Kupeli I. Effect of preemptive intravenous ibuprofen on postoperative edema and trismus in third molar tooth extraction: A randomized controlled study. J Dent Anesth Pain Med. 2018;18(3):161-7. [Crossref]  [PubMed]  [PMC] 
  19. Esparza-Villalpando V, Chavarria-Bola-os D, Gordillo-Moscoso A, Masuoka-Ito D, Martinez-Rider R, Isiordia-Espinoza M, et al. Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: a randomized clinical trial. J Craniomaxillofac Surg. 2016;44(9):1350-5. [Crossref]  [PubMed] 
  20. Aznar-Arasa L, Harutunian K, Figueiredo R, Valmaseda-Castellón E, Gay-Escoda C. Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. Int J Oral Maxillofac Surg. 2012;41(8):1005-9. [Crossref]  [PubMed] 
  21. Morse Z, Tump A, Kevelham E. Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery. Odontology. 2006;94(1):59-63. [Crossref]  [PubMed] 

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