Journal of Traditional Medical Complementary Therapies

.: ORIGINAL RESEARCH
Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials
Akupunkturun, Obez Kadınlardaki Kolesterol, Antioksidan ve Oksidan Parametreler Üzerine Etkileri: Klinik Deneyler
Şebnem Setenay MİTa, Çınar SEVERCANb, Ersel GEÇİOĞLUa, Ayşe Banu ÇAYCI SİVRİc, Canan YILMAZc, Funda GÜÇELc, Cemal ÇEVİKd
aGazi University Faculty of Medicine, Acupuncture and Complementary Medicine Center, Ankara, Türkiye
bDepartment of Biochemistry, Zonguldak Bülent Ecevit University Faculty of Pharmacy, Zonguldak, Türkiye
cDepartment of Medical Biochemistry, Gazi University Medicine Faculty, Ankara, Türkiye
dDepartment of Medical Biochemistry, Lokman Hekim University Medicine Faculty, Ankara, Türkiye
J Tradit Complem Med. 2022;5(2):96-105
doi: 10.5336/jtracom.2021-87383
Article Language: EN
Full Text
ABSTRACT
 Objective: Obesity has a profound adverse impact on health care systems. Acupuncture has been shown to have beneficial effects on obesity. The aim of this study is to investigate the effects of acupuncture on serum oxidative stress parameters in obese women. Material and Methods: During the study, 20 obese patients had acupuncture treatment, and as a control group, 20 obese patients had sham acupuncture treatment. Serum samples were taken from each patient before the first session and at the end of the 10th session and serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, malondialdehyde (MDA), advanced oxidation protein products (AOPP), the serum activity of superoxide dismutase enzyme (SOD) and glutathione peroxidase enzyme (GPx) were measured. Results: Changes in the serum levels of TG, HDL, MDA, AOPP and activity of SOD after the treatment compared to before the treatment in both acupuncture and sham acupuncture treated groups were found insignificant (p>0.05). On the other hand, the TC and LDL levels were observed to decrease significantly in comparison to the before-treatment values in both the acupuncture and sham acupuncture groups (p<0.05). In addition to this, the GPx activity significantly increased only as a result of the acupuncture treatment (p<0.05). Conclusion: The results of our study indicated that acupuncture treatment may be effective in reducing cholesterol levels and increasing the activity of antioxidant enzymes.

Keywords: Acupuncture; obesity; cholesterol; oxidative stress; antioxidants
ÖZET
 Amaç: Obezite, bireyin sağlığı üzerinde olumsuz etkiye sahiptir. Akupunktur tedavisinin obezite üzerinde olumlu etkileri olduğu gösterilmiştir. Bu çalışmanın amacı, obez kadınlarda akupunkturun serum oksidatif stres parametreleri üzerindeki etkilerini araştırmaktır. Gereç ve Yöntemler: Çalışma süresince 20 obez bireye akupunktur tedavisi, kontrol grubu olarak 20 obez bireye sham akupunktur tedavisi uygulanmıştır. Her hastadan ilk seans öncesi ve 10. seans sonunda serum örnekleri alınarak toplam kolesterol [total cholesterol (TC)], trigliseridler (TG), yüksek yoğunluklu lipoprotein [high-density lipoprotein (HDL)] kolesterol ve düşük yoğunluklu lipoprotein [low-density lipoprotein (LDL)] kolesterol serum seviyeleri alınmıştır. Alınan serum örnekleri üzerinden kolesterol, malondialdehit (MDA), ileri oksidasyon protein ürünleri [advanced oxidation protein products (AOPP)], süperoksit dismutaz enzimi (SOD) ve glutatyon peroksidaz enzimi (GPx) serum aktivitesi ölçülmüştür. Bulgular: Hem akupunktur hem de sham akupunktur uygulanan gruplarda tedavi öncesi ile karşılaştırıldığında, tedavi sonrası serum TG, HDL, MDA, AOPP ve SOD aktivitesindeki farkın anlamlılığı bulunamamıştır (p>0,05). Buna rağmen hem akupunktur hem de sham akupunktur gruplarında TC ve LDL düzeylerinin tedavi öncesi değerlere göre anlamlı derecede düştüğü gözlenmiştir (p<0,05). Ek olarak, GPx aktivitesi sadece akupunktur tedavisi sonucunda anlamlı olarak artmıştır (p<0,05). Sonuç: Çalışmamızın sonuçları, akupunktur tedavisinin kolesterol düzeylerini düşürmede ve antioksidan enzimlerin aktivitesini artırmada etkili olabileceğini göstermiştir.

Anahtar Kelimeler: Akupunktur; obezite; kolesterol; oksidatif stres; antioksidanlar
REFERENCES:
  1. World Health Organization [Internet]. © 2019 WHO. Obesity and overweight. [Cited: June 5, 2019]. Available from: [Link] 
  2. Rani V, Deep G, Singh RK, Palle K, Yadav UC. Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci. 2016;148:183-93. [Crossref]  [PubMed] 
  3. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118-26. [Crossref]  [PubMed]  [PMC] 
  4. Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014;16(1):378-400. [Crossref]  [PubMed]  [PMC] 
  5. Moselhy HF, Reid RG, Yousef S, Boyle SP. A specific, accurate, and sensitive measure of total plasma malondialdehyde by HPLC. J Lipid Res. 2013;54(3):852-8. [Crossref]  [PubMed]  [PMC] 
  6. Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, et al. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother. 2015;74:101-10. [Crossref]  [PubMed] 
  7. Taylor EL, Armstrong KR, Perrett D, Hattersley AT, Winyard PG. Optimisation of an advanced oxidation protein products assay: its application to studies of oxidative stress in diabetes mellitus. Oxid Med Cell Longev. 2015;2015:496271. [Crossref]  [PubMed]  [PMC] 
  8. Guerra RC, Zu-iga-Mu-oz A, Guarner Lans V, Díaz-Díaz E, Tena Betancourt CA, Pérez-Torres I. Modulation of the activities of catalase, cu-zn, mn superoxide dismutase, and glutathione peroxidase in adipocyte from ovariectomised female rats with metabolic syndrome. Int J Endocrinol. 2014;2014:175080. [Crossref]  [PubMed]  [PMC] 
  9. Yao J, He Z, Chen Y, Xu M, Shi Y, Zhang L, et al. Acupuncture and weight loss in Asians: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2019;98(33):e16815. [Crossref]  [PubMed]  [PMC] 
  10. Zhang A, Sun H, Yan G, Cheng W, Wang X. Systems biology approach opens door to essence of acupuncture. Complement Ther Med. 2013;21(3):253-9. [Crossref]  [PubMed] 
  11. Cabioğlu MT, Ergene N. Electroacupuncture therapy for weight loss reduces serum total cholesterol, triglycerides, and LDL cholesterol levels in obese women. Am J Chin Med. 2005;33(4):525-33. [Crossref]  [PubMed] 
  12. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351-8. [Crossref]  [PubMed] 
  13. Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, et al. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996;49(5):1304-13. [Crossref]  [PubMed] 
  14. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34(3):497-500. [Crossref]  [PubMed] 
  15. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158-69. [PubMed] 
  16. Jayawardena R, Ranasinghe P, Ranathunga T, Mathangasinghe Y, Wasalathanththri S, Hills AP. Novel anthropometric parameters to define obesity and obesity-related disease in adults: a systematic review. Nutr Rev. 2020;78(6):498-513. [Crossref]  [PubMed] 
  17. Mauvais-Jarvis F. Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ. 2015;6:14. [Crossref]  [PubMed]  [PMC] 
  18. Liang F, Koya D. Acupuncture: is it effective for treatment of insulin resistance? Diabetes Obes Metab. 2010;12(7):555-69. [Crossref]  [PubMed] 
  19. Belivani M, Dimitroula C, Katsiki N, Apostolopoulou M, Cummings M, Hatzitolios AI. Acupuncture in the treatment of obesity: a narrative review of the literature. Acupunct Med. 2013;31(1):88-97. [Crossref]  [PubMed] 
  20. Alp H. Evaluation of anthropometric results after acupuncture and diet applications in obesity patients:an experimental-control study. Acupunct Electrother Res. 2021;45(2-4):97-106. [Crossref] 
  21. He J, Zhang X, Qu Y, Huang H, Liu X, Du J, et al. Effect of combined manual acupuncture and massage on body weight and body mass index reduction in obese and overweight women: a randomized, short-term clinical trial. J Acupunct Meridian Stud. 2015;8(2):61-5. [Crossref]  [PubMed] 
  22. Güçel F, Bahar B, Demirtas C, Mit S, Cevik C. Influence of acupuncture on leptin, ghrelin, insulin and cholecystokinin in obese women: a randomised, sham-controlled preliminary trial. Acupunct Med. 2012;30(3):203-7. [Crossref]  [PubMed] 
  23. Chen J, Chen D, Ren Q, Zhu W, Xu S, Lu L, et al. Acupuncture and related techniques for obesity and cardiovascular risk factors: a systematic review and meta-regression analysis. Acupunct Med. 2020;38(4):227-34. [Crossref]  [PubMed] 
  24. Kim KW, Shin WC, Choi MS, Cho JH, Park HJ, Yoo HH, et al. Effects of acupuncture on anthropometric and serum metabolic parameters in premenopausal overweight and obese women: a randomized, patient- and assessor-blind, sham-controlled clinical trial. Acupunct Med. 2021;39(1):30-40. [Crossref]  [PubMed] 
  25. McMurray F, Patten DA, Harper ME. Reactive oxygen species and oxidative stress in obesity-recent findings and empirical approaches. Obesity (Silver Spring). 2016;24(11):2301-10. [Crossref]  [PubMed] 
  26. Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017;524:13-30. [Crossref]  [PubMed] 
  27. Melough MM, Sun X, Chun OK. The role of AOPP in age-related bone loss and the potential benefits of berry anthocyanins. Nutrients. 2017;9(7):789. [Crossref]  [PubMed]  [PMC] 
  28. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9-19. [Crossref]  [PubMed]  [PMC] 
  29. Morais JB, Severo JS, Santos LR, de Sousa Melo SR, de Oliveira Santos R, de Oliveira AR, et al. Role of magnesium in oxidative stress in ındividuals with obesity. Biol Trace Elem Res. 2017;176(1):20-26. [Crossref]  [PubMed] 
  30. Manna P, Jain SK. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord. 2015;13(10):423-44. [Crossref]  [PubMed]  [PMC] 
  31. Mangge H, Summers K, Almer G, Prassl R, Weghuber D, Schnedl W, et al. Antioxidant food supplements and obesity-related inflammation. Curr Med Chem. 2013;20(18):2330-7. [Crossref]  [PubMed] 
  32. Jiang YL, Ning Y, Liu YY, Wang Y, Zhang Z, Yin LM, et al. Effects of preventive acupuncture on streptozotocin-induced hyperglycemia in rats. J Endocrinol Invest. 2011;34(10):e355-61. [PubMed] 
  33. Wang LH, Huang W, Wei D, Ding DG, Liu YR, Wang JJ, et al. Mechanisms of acupuncture therapy for simple obesity: an evidence-based review of clinical and animal studies on simple obesity. Evid Based Complement Alternat Med. 2019;2019:5796381. [Crossref]  [PubMed]  [PMC] 
  34. Öztaş D, Erdoğan S, Koroglu FT, Mollahaliloglu S, Erel O. Useful influence of ear & body acupuncture treatment on the significant reduction of body weight of obesity and its relationship with oxidant-antioxidant system. Acupunct Electrother Res. 2019;43:333-47. [Crossref] 
  35. Mazidi M, Abbasi-Parizad P, Abdi H, Zhao B, Rahsepar AA, Tavallaie S, et al. The effect of electro-acupuncture on pro-oxidant antioxidant balance values in overweight and obese subjects: a randomized controlled trial study. J Complement Integr Med. 2017;15(2):/j/jcim.2018.15.issue-2/jcim-2015-0081/jcim-2015-0081.xml. [Crossref]  [PubMed] 

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