Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Effect of Calcium and Phosphorus Metabolism on Static and Dynamic Pupillary Responses: Prospective Cross-Sectional Study
Kalsiyum ve Fosfor Metabolizmasının Statik ve Dinamik Pupil Yanıtları Üzerine Etkisi: Prospektif Kesitsel Araştırma
Tuğçe HOROZOĞLU CERANa , Mehmet Ali ŞEKEROĞLUa , Ali Mert KOÇERb , Çağatay Emir ÖNDERc, Şerife Mehlika KUŞKONMAZd
aClinic of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Türkiye
bClinic of Ophthalmology, Arnavutköy State Hospital, İstanbul, Türkiye
cClinic of Internal Medicine, Niğde Ömer Halisdemir University Training and Research Hospital, Niğde, Türkiye
dClinic of Endocrinology and Metabolic Diseases, Ankara Training and Research Hospital, Ankara, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(2):67-73
doi: 10.5336/ophthal.2022-91508
Article Language: EN
Full Text
ABSTRACT
 Objective: To investigate the effects of serum calcium and phosphorus levels on static and dynamic pupillometry measurements in patients with postoperative hypoparathyroidism. Material and Methods: Pupillometry measurements were undertaken by using an automatic pupillometry to detect high photopic, low photopic, mesopic, scotopic pupil diameters with amplitude, latency, duration and velocity of pupil contraction and dilatation. Duration of hypoparathyroidism and serum parathyroid hormone (PTH), calcium and phosphorus levels were recorded. Results: This study included 46 female patients with postoperative hypoparathyroidism and 61 healthy female participants. There were no significant differences between the pupil diameters at different light intensities between the study groups (p>0.05 for all). Among the dynamic pupillometric measurements, pupil contraction amplitude was significantly higher in patients with postoperative hypoparathyroidism when compared to that of healthy controls (1.85±0.04 mm vs 1.72±0.03 mm respectively, p=0.018). There was no significant correlation between the duration of hypoparathyroidism, serum calcium, phosphorus, and PTH levels with static and dynamic pupillometry values (p>0.05 for all), with an exception of a positive correlation between the serum calcium level and amplitude of contraction (r=0.322, p=0.029). Conclusion: Pupil diameters at different light intensities were not affected in patients with postoperative hypoparathyroidism, but pupil contraction amplitude was higher than in healthy individuals.

Keywords: Calcium; hypoparathyroidism; parathyroid hormone; phosphorus; pupil disorders
ÖZET
 Amaç: Bu çalışmanın amacı, postoperatif hipoparatiroidili hastalarda serum kalsiyum ve fosfor düzeylerinin statik ve dinamik pupil yanıtları üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntemler: Yüksek fotopik, düşük fotopik, mezopik ve skotopik ortamlardaki pupil çapını, pupil kontraksiyonu ve dilatasyonunun amplitüdünü, latansını, süresini ve hızını tespit etmek için otomatik bir kantitatif pupillometri sistemi kullanılarak pupillometri ölçümleri yapıldı. İstatistiksel analiz için hastaların sağ gözlerinden alınan veriler kullanıldı. Hipoparatiroidizm süresi ile serum paratiroid hormon, kalsiyum ve fosfor düzeylerinin bu verilere etkisi araştırıldı. Bulgular: Çalışmaya postoperatif hipoparatiroidili 46 kadın hasta ve 61 sağlıklı kadın kontrol grubu dâhil edildi. İki grup arasında farklı ışık yoğunluklarında pupil çapları arasında istatistiksel olarak anlamlı bir farklılık izlenmedi (tümü için p>0,05). Dinamik pupillometrik ölçümlerden olan pupilla kontraksiyon amplitüdü istatistiksel olarak anlamlı olarak postoperatif hipoparatiroidili hastalarda sağlıklı katılımcı grubuna göre yüksek bulundu (sırasıyla 1,85±0,04 mm'ye karşı 1,72±0,03 mm, p=0,018). Hipoparatiroidizm süresi, serum kalsiyum, fosfor ve paratiroid hormon düzeyleri ile statik ve dinamik pupillometri yanıtları arasında istatistiksel olarak anlamlı bir ilişki yoktu (tümü için p>0,05). İstisna olarak serum kalsiyum düzeyi ve kontraksiyon amplitüdü arasında pozitif korelasyon tespit edildi (r=0,322, p=0,029). Sonuç: Postoperatif hipoparatiroidili hastalarda farklı ışık şiddetlerinde pupil çaplarında farklılık tespit edilmezken, pupil kontraksiyon amplitüdü sağlıklı bireylere göre daha yüksek bulundu.

Anahtar Kelimeler: Kalsiyum; hipoparatiroidi; paratiroid hormonu; fosfor; pupil bozuklukları
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