Pharmacology and COVID-19

COVID-19 ve Gıda Takviyeleri ve Vitaminler
COVID-19 and Food Supplements and Vitamins
Emine AKALINa, Mehmet BAYKALb, Ali Yağız ÜRESİNc,dc,d
aİstanbul Üniversitesi Eczacılık Fakültesi, Farmasötik Botanik ABD, İstanbul, TÜRKİYE
bİstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Farmakoloji ABD, İstanbul, TÜRKİYE
cİstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Farmakoloji ABD, Klinik Farmakoloji BD, İstanbul, TÜRKİYE
dİstanbul Üniversitesi Klinik Araştırmalar Mükemmeliyet Araştırma ve Uygulama Merkezi, İstanbul, TÜRKİYE
Akalın E, Baykal M, Üresin AY. COVID-19- gıda takviyeleri ve vitaminler. Üresin AY, editör. Farmakoloji ve COVID-19. 1. Baskı. Ankara: Türkiye Klinikleri; 2021. p.74-92.
Article Language: TR
ÖZET
Koronavirüs hastalığına (COVID-19) bağlı olarak, 22 Ocak 2021 itibariyle dünya ölçeğinde 96.2 milyon kişi etkilenmiş ve 2.06 milyon kişi hayatını kaybetmiştir. Şu anki bilgilerimize göre bulaş hızının yüksekliği, immün yetmezlik ve düşük bağışıklık düzeyinin hastalıktan etkilenmede önemli olduğu, tam tersine yüksek bağışıklık yanıtının mortal seyretmesinde rol aldığı görülmüştür. Bu durum bağışıklık sistemini güçlendirecek veya düzenleyecek takviye unsurların diyet yoluyla alınmasını gündeme getirmiştir. Vitamin ve destekleyici diyet unsurlarının kullanımının hastalıktan koruma kadar hastalığın şiddetini azaltmada ve seyrini düzeltmede etkin olduğuna ilişkin her geçen gün artan sayıda kanıta-dayalı rapor bulunmaktadır. Bu gözden geçirme yazısında hastalık etkeni ve hastalık için kullanılan vitamin ve gıda takviyelerinin yer aldığı çalışmalar arama motorları üzerinden bulunarak incelendi. Yağda eriyen vitaminlerden A, E ve D vitaminlerinin hastalıktan korumada ve gelişti ise hastalığın şiddetini azaltmada etkin olduğunu bildiren yayınlar kadar, bu sonucu desteklemeyen çalışmaların da olduğu gözlenmiştir. Bununla birlikte son zamanlarda bu ve benzeri preparatların yüksek oranlarda kullanımının yol açtığı/açabileceği olumsuzluklar da rapor edilmeye başlandığı dikkati çekmektedir.

Anahtar Kelimeler: SARS-CoV-2; COVID-19; vitamin; bitkisel ürün; bağışıklık-aracılıklı inflamatuar yanıt
ABSTRACT
Due to coronavirus disease (COVID-19) 96.2 million people worldwide were affected and 2.06 million people died as of January 22th. According to our recent knowledge, the high rate of transmission, immunodeficiency and low immunity are significant in being affected by the disease, in the contrary high immune response takes part in the high mortality rate. In these circumstances, the intake of supplements that will strengthen and regulate the immune system through diet is brought to the agenda. There are an increasing number of evidence-based reports that the use of vitamins and supplementary dietary components is effective in reducing disease severity and improving its course as well as protection from disease. In this review article, studies on the disease agent and vitamins and food supplements used for the disease were found and examined through search engines. It has been observed that there are studies that do not support this result, as well as publications reporting that vitamins A, E and D, which are among the fat-soluble vitamins, are effective in protecting from the disease and reducing the severity of the disease. However, it is noteworthy that recently, the negativities caused/may be caused by the high rates of use of these and similar preparations have started to be reported.

Keywords: SARS-CoV-2; COVID-19; vitamins; herbal supplements; immun-inflammatory response

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30.03.2014

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