Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonu; 2019 yılı Aralık ayında, Çin'in Hubei eyaletinin Wuhan şehrinde ilk kez tanımlanmıştır. Etken virüs, 2002 yılında tanımlanan şiddetli akut solunum sendromu [severe acute respiratory syndrome (SARS)] virüsü ile benzerliği sebebiyle SARSCoV-2 olarak isimlendirilmiştir. Hızla yayılan enfeksiyon, 11 Mart 2020 tarihinde Dünya Sağlık Örgütü tarafından pandemi olarak duyurulmuştur. Hastalığın klinik belirtileri, oldukça geniş bir yelpazede seyretmektedir. En sık görülen semptomlar ateş, kuru öksürük, miyalji veya yorgunluk ile nefes darlığıdır. Virüsün bulaşıcılığı, önceki yıllarda tanımlanan CoV'lere oranla çok daha yüksektir. Asemptomatik kişilerin, bulaştırıcı olabileceği de bildirilmiştir. Hastalık tanısı, genellikle nazofarengeal sürüntü örneklerine revers transkripsiyon-polimeraz zincir reaksiyonu testi yapılarak konulmaktadır. Direkt grafi ve bilgisayarlı tomografi, tanıda destekleyicidir. Hastalığın prognozunda, immün sistem fonksiyonları önemli rol oynamaktadır. Ölümle sonuçlanan olgularda, genellikle kronik ek hastalıklar mevcuttur. COVID-19 enfeksiyonunda, adli tıp polikliniklerinde acil olmayan muayeneler ertelenmiştir. Kliniklerde çalışan adli tıp uzmanı ve yardımcı personel, standart kişisel koruyucu ekipman önlemlerine uygun giyinmelidir. Postmortem işlemler sırasında morg çalışanları, çok yüksek riskli sınıfta kabul edildiğinden standart önlemlere ek olarak en az FFP2 ya da N95 maske, yüz koruyucu siperlik, plastik dezenfekte edilebilir çizme ve su geçirmez önlük kullanmalıdır. Postmortem incelemeler sırasında otopsi kararı verilirken, adli tıp kurumunun yayımladığı algoritmalara uygun olarak öncelikle nazofarengeal örnek alınarak sonucu beklenmelidir. Pozitif olgularda, mümkünse ölü muayenesi ile defin ruhsatı verilmelidir. Adli olgulara otopsi, mümkünse negatif basınçlı salonlarda yapılmalıdır. COVID-19 enfeksiyonunda yapılan sınırlı sayıdaki otopsi çalışmalarında; yaygın alveoler hasar, havayolu inflamasyonu, plörezi, perikardit, akciğer konsolidasyonu ve pulmoner ödem gibi ağırlıklı olarak solunum sistemi patolojileri saptanmıştır.
Anahtar Kelimeler: COVID-19; adli tıp; otopsi; primer korunma
Coronavirus disease-2019 (COVID-19) infection was first described in the city of Wuhan in the Hubei province of China in December 2019. The causative virus was named SARS-CoV-2 due to its similarity with the severe acute respiratory syndrome (SARS) virus identified in 2002. The rapidly spreading infection was announced as a pandemic by the World Health Organization on March 11, 2020. The clinical symptoms of the disease have a wide range. The most common symptoms are fever, dry cough, myalgia or fatigue, and shortness of breath. The infectiousness of the virus is much higher than the CoVs described in previous years. It has also been reported that asymptomatic individuals can become infectious. The disease is generally diagnosed by performing reverse transcription-polymerase chain reaction test in nasopharyngeal swab samples. Direct X-ray and computed tomography are supportive of the diagnosis. Immune system functions play an important role in the prognosis of the disease. Chronic additional diseases are generally present in cases that result in death. Non-urgent examinations were postponed in forensic medicine outpatient clinics in COVID-19 infection. Forensic medicine specialists working in clinics and auxiliary personnel should be dressed following the standard personal protective equipment measures. Morgue workers should use at least FFP2 or N95 masks, face protection visors, plastic disinfectable boots, and waterproof gowns during post-mortem procedures in addition to standard measures, as they are considered to be in a very high-risk class. Firstly nasopharyngeal samples should be taken following the algorithms published by the council of forensic medicine and the result should be waited while making an autopsy decision during post-mortem examinations. In positive cases, if possible, a burial permit should be given with a death examination. Forensic cases should be performed in negative pressure salons if possible. Predominantly respiratory system pathologies such as diffuse alveolar damage, airway inflammation, pleurisy, pericarditis, lung consolidation, and pulmonary edema have been identified in the limited number of autopsy studies performed in COVID-19 infection.
Keywords: COVID-19; forensic medicine; autopsy; primary prevention
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