Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Comparison of Some Plasma Inflammation Markers in Elite Master Athletes, Recreational Athletes and Sedentary Males
Elit Master Atletler, Rekreasyonal Atletler ve Sedanter Erkeklerde Bazı Plazma İnflamasyon Markerlerinin Karşılaştırılması
Fatma GİRGİNERa, Gürbüz BÜYÜKYAZI(1954-2018)b, Cevval ULMANc, Yeliz DOĞRUd, Fatma TANELİc, Raziye YILDIZe, Murat TAŞf, Pembe KESKİNOĞLUg
aHacı Serpil Kabaklıoğlu Secondary School, Denizli, TURKEY
bDepartment of Trainer Training, Dokuz Eylül University, Faculty of Sports Sciences, İzmir, TURKEY
cDepartment of Biochemistry, Manisa Celal Bayar University, Faculty of Medicine, Manisa, TURKEY
dDeparment of Sports, İzmir Katip Çelebi University, Deparment of Sports, İzmir, TURKEY
eClinic of Biochemistry Laboratory, Akçaabat Haçkalı Baba State Hospital, Trabzon, TURKEY
fManisa Celal Bayar University, Faculty of Sports Sciences, Manisa, TURKEY
gDepartment of Biostatistics, Dokuz Eylül University, Faculty of Medicine, İzmir, TURKEY
Turkiye Klinikleri J Med Sci. 2019;39(2):202-11
doi: 10.5336/medsci.2018-63235
Article Language: EN
Full Text
ABSTRACT
 Objective: It is known that high-intensity exercises lead to muscle damage and fibrosis. This study aims to compare some plasma inflammation markers in elite master athletes, recreational athletes and sedentary males to determine muscle injury. Material and Methods: 60 healthy male participants (min-max 45-65 years) were divided into 3 groups: Elite master athletes performing high intensity training (EMAG; n=22), recreational athletes performing moderate intensity training (RG; n=21) and sedentary controls (CG; n=17). Resting serum levels of the monocyte chemoattractant protein-1 (MCP-1), High-Sensitivity C-Reactive Protein (hsCRP), Tumor Necrosis Factor Alfa (TNF-α), Transforming Growth Factor Beta-1 (TGF-β-1), and Klotho hormone were compared among the groups. Results: Body weight, fat percentages, body mass index were lower and MaxVO2 was higher in EMAG than those of both RG and CG. TGF-β-1 and Klotho Hormone levels of EMAG and RG were higher than CG. Vitamin D levels of EMAG were found higher than those of CG. Conclusion: Regular long-term endurance training has a long-term positive impact on the regeneration of muscle damage and inflammation. The high levels of Klotho hormone determined in EMAG provides a longer and healthier life by extending the initiation process of many illnesses including metabolic diseases.

Keywords: Master athletes; recreational athletes; hsCRP; MCP-1; TGF-β-1; klotho hormone
ÖZET
 Amaç: Yüksek şiddette egzersizin kas hasarı ve fibrozise yol açtığı bilinmektedir. Bu çalışma kas yaralanmasını belirlemek için elit master atletler, rekreasyonal atletler ve sedanter erkeklerde bazı plazma inflamasyon markerlerini karşılaştırmayı amaçlamaktadır. Gereç ve Yöntemler: 60 sağlıklı erkek (min-maks: 45-65 yıl) yüksek şiddette antrenman yapan elit master atletler (EMAG; n=22), orta şiddette antrenman yapan rekreasyonal atletler (RG; n=21) ve sedanter kontroller (KG; n=17) olmak üzere üç gruba ayrıldı. Monocyte Chemoattractant Protein-1 (MCP-1), Yüksek hassasiyetli C-Reaktif Protein (hsCRP), Tumor Necrosis Factor Alpha (TNF-α), Transforming Growth Factor Beta-1 (TGF-β-1) ve Klotho hormon istirahat düzeyleri üç grupta karşılaştırıldı. Bulgular: EMAG'ın vücut ağırlığı, yağ yüzdesi ve vücut kütle indeksi değerleri RG ve CG'den daha düşük; MaxVO2 değerleri ise daha yüksekti. EMAG'ın TGF-β-1 ve Klotho hormon düzeyleri hem RG'den hem de CG'den istatistiksel olarak daha yüksekti. EMAG'ın Vitamin D değerleri ise CG'den istatistiksel olarak daha yüksek bulundu. Sonuç: Uzun süre yapılan dayanıklılık antrenmanının kas hasarı ve inflamasyonun rejenerasyonu üzerine olumlu etkisi vardır. EMAG'da belirlenen yüksek düzeylerdeki Klotho hormonu metabolik hastalıklar da dahil pek çok hastalığın başlangıç sürecini uzatarak daha uzun ve daha sağlıklı bir yaşam sağlar.

Anahtar Kelimeler: Master atletler; rekreasyonal atletler; hsCRP; MCP-1; TGF-β-1; klotho hormon
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