Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Comparison of Antibiotic Pastes for Tooth Discoloration and Internal Bleaching: An in vitro Study
Antibiyotikli Patların Dişlerdeki Renk Değişikliği ve İnternal Beyazlatma Açısından Karşılaştırılması: in vitro Çalışma
Esma SARIÇAMa
aAnkara Yıldırım Beyazıt University Faculty of Dentistry, Department of Endodontics, Ankara, Türkiye
Turkiye Klinikleri J Dental Sci. 2024;30(4):624-30
doi: 10.5336/dentalsci.2024-103983
Article Language: EN
Full Text
ABSTRACT
 Objective: The goal of this research was to examine the color changes that occurred after using various versions of triple antibiotic pastes (TAP) and the teeth-whitening effects of sodium perborate on these colored teeth. Material and Methods: The endodontic access cavities of thirty extracted bovine incisors were prepared and then the root canals were enlarged to mimic the immature teeth. The samples were separated into three groups based on the intracanal antibiotic paste placement, TAP-D: mix of metronidazole, ciprofloxacin, and doxycycline, TAP-C: mix of cefaclor, metronidazole, and ciprofloxacin, and TAP-A: mix of amoxicillin+clavulonic acid, metronidazole, and ciprofloxacin. The pastes were inserted into the root canals. After 3 weeks, the pastes were removed. Sodium perborate was placed into the access cavities for bleaching and replaced every week for 3 weeks. Spectrophotometric measurements were obtained at baseline and every week for six weeks. The ΔE value was calculated and analyzed using a two-way analysis of variance and post-hoc Tukey's test (p=0.05). Results: Color changes in the TAP-A were statistically significantly higher than the values obtained with TAP-C (p<0.001), and TAP-D (p<0.001). There was no statistically significant difference between TAP-C and TAP-D (p>0.05). For every group, the agent's bleaching impact was statistically similar (p>0.05). Conclusion: Mix of amoxicillin+clavulonic acid, metronidazole, and ciprofloxacin caused more discoloration than the other pastes. Sodium perborate provided same bleaching effect on all types of paste groups.

Keywords: Amoxicillin-clavulanic acid combination; cefaclor; regenerative endodontics; tooth bleaching; tooth discoloration
ÖZET
 Amaç: Bu çalışmanın amacı, çeşitli kombinasyonlardaki üçlü antibiyotikli patların (ÜAP) kullanımı sonrasında oluşan renk değişikliklerini ve sodyum perboratın renklenmiş dişler üzerindeki beyazlatma etkinliklerini incelemektir. Gereç ve Yöntemler: Otuz adet çekilmiş sığır keser dişin endodontik giriş kavitelerinin preparasyonu yapıldı ve daha sonra kök kanalları olgunlaşmamış dişleri taklit edecek şekilde genişletildi. Örnekler kanal içi antibiyotik pat yerleşimine göre ÜAPD: Metronidazol, siprofloksasin ve doksisiklin karışımı, ÜAP-S: Sefaklor, metronidazol ve siprofloksasin karışımı ve ÜAP-A: Amoksisilin+klavulanik asit, metronidazol ve siprofloksasin karışımı olmak üzere 3 gruba ayrıldı. Patlar kök kanallarına yerleştirildi. Üç hafta sonra patlar uzaklaştırıldı. Giriş kavitelerine beyazlatma amacıyla sodyum perborat yerleştirildi ve 3 hafta boyunca her hafta değiştirildi. Spektrofotometrik ölçümler başlangıçta ve 6 hafta boyunca her hafta yapıldı. ΔE değeri, iki yönlü varyans analizi ve ''post hoc'' Tukey testi kullanılarak hesaplandı ve analiz edildi (p=0,05). Bulgular: ÜAP-A grubundaki renk değişikliği, ÜAP-S ve ÜAP-D ile elde edilen değerlerden istatistiksel olarak anlamlı derecede yüksekti (p<0,001). ÜAPS ve ÜAP-D arasında istatistiksel olarak anlamlı seviyede fark yoktu (p>0,05). Her grup için ajanın ağartma etkisi istatistiksel olarak benzerdi. (p>0,05). Sonuç: Amoksisilin+klavulanik asit, metronidazol ve siprofloksasin karışımı, diğer patlara kıyasla daha fazla renk değişikliğine neden oldu. Sodyum perborat tüm pat gruplarında aynı ağartma etkisini sağladı.

Anahtar Kelimeler: Amoksisilin-klavulanik asit kombinasyonu; sefaklor; rejeneratif endodonti; diş beyazlatma; dişte renk değişikliği
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