Turkiye Klinikleri Journal of Pediatrics

.: ORIGINAL RESEARCH
Çocuklarda Sık Kullanılan Antiepileptik Solüsyonların Tat ve Kokularının Tedavi Uyumuna Etkisinin Değerlendirilmesi: Kesitsel Tanımlayıcı Araştırma
The Effect of Taste and Smell of Commonly Used Antiepileptic Solutions in Children on Treatment Compliance: Cross-Sectional Descriptive Research
Aslıhan İZOLa , Selçuk YAZICIa , Hilal AYDINa
aBalıkesir Üniversitesi Tıp Fakültesi, Çocuk Sağlığı Hastalıkları ABD, Balıkesir, Türkiye
Turkiye Klinikleri J Pediatr. 2024;33(1):16-24
doi: 10.5336/pediatr.2023-101081
Article Language: TR
Full Text
ÖZET
 Amaç: Çalışmamızın amacı, solüsyon formda antiepileptik kullanan çocuklarda, ilacın tat ve kokularının tedaviye uyuma etkisini değerlendirmektir. Gereç ve Yöntemler: Balıkesir Üniversitesi Hastanesi, Çocuk Nöroloji Polikliniğinde epilepsi nedeniyle takipli olan hastaların çalışmaya katılmayı kabul eden ebeveynlerine, çocuklarının antiepileptik ilaçlara uyumuyla ilgili, gönüllü katılıma dayalı anket uygulanması şeklinde yapılmıştır. Çalışmada kullanılan anket soruları literatürde bulunan benzer çalışmalardaki anket sorularının revize edilmesi ile hazırlanmıştır. Çalışmaya alınan gönüllü sayısı poliklinikte takip edilen hastalar üzerinden oluşturulmuştur. Hastalar 18 yaşından küçük olduğu için anket soruları gönüllü bakımverenler tarafından yanıtlanmıştır. Bulgular: Çalışmaya 102 epilepsi tanılı oral antiepileptik solüsyon kullanan hasta dâhil edildi. Hastaların 83'ünün (81,37) monoterapi, 19'unun (%18,63) politerapi aldığı saptanmıştır. Hastaların kullandıkları ilaçlar incelendiğinde 47'sinin (%46,08) Keppra®, 26'sının (%25,49) Depakin®, 15'inin (%14,71) Epixx®, 12'sinin (%11,76) Convulex®, 4'ünün (%3,92) Trileptal®, 4'ünün (%3,92) Tegretol® kullandığı saptanmıştır. Sadece Keppra® kullananların ilacı iyi olarak değerlendirmesi oranı kullanmayanlardan yüksek saptanmıştır (p=0,042). Hastaların tedaviye uyumu zorlaştıran faktörlere verdikleri yanıtlar incelendiğinde 24'ünün (%23,53) ilaç tadını beğenmeme, 16'sının (%15,69) unutkanlık, 3'ünün (%2,94) nöbetlerin azalması olarak yanıtladığı saptanmıştır. Sonuç: Çocuk hastalarda antiepileptik ilaç tedavisine uyumda ailelerin karşılaştığı en büyük güçlük hastanın ilacın tadını beğenmemesidir. Bu durum, antiepileptik ilaçların tadına yönelik yeni ilaç teknolojilerinin geliştirilmesinin gerekli olduğunu göstermiştir. Antiepileptik ilaçlarla yapılacak tat çalışmalarının, eklenen aromalar, yardımcı veya tatlandırıcı maddelerin çeşit, sayı ve miktarının standardize edildiği, özdeş, aynı fiziksel yapıda, karşılaştırılabilir preparatlar ile yapılmasında yarar olduğu düşüncesindeyiz.

Anahtar Kelimeler: Epilepsi; tedavi uyumsuzluğu; antikonvülzanlar
ABSTRACT
 Objective: The aim of our study is to evaluate the effect of the taste and smell of the drug on compliance with treatment in children using antiepileptics in syrup form. Material and Methods: A voluntary participation-based survey was administered to the parents of patients who were followed up due to epilepsy at the Child Neurology Clinic of Balıkesir University Hospital, who agreed to participate in the study, regarding their children's compliance with antiepileptic drugs. The survey questions used in the study were prepared by revising the survey questions in similar studies in the literature. The number of volunteers included in the study was determined by the patients followed in the outpatient clinic. The survey questions were answered by caregivers voluntiarily because the patients were under 18 years. Results: 102 epileptic patients using oral antiepileptic solutions were included in the study. 46.08% of the patients were using Keppra®, 25.49% were using Depakin®, 14.71% were using Epixx®, 11.76% were using Convulex®, 3.92% were using Trileptal®, and 3.92% were using Tegretol®. The rate of evaluating the drug taste as good was found to be higher only in patients using Keppra® than in those not using it (p=0.042). The most common factors that reduced patients' compliance with treatment were dislike of the taste of the medicine (23.53%), forgetfulness (15.69%) and a decrease in seizures (2.94%). 40.20% of the parents gave supplements that would change the taste of the medicine. Conclusion: The biggest difficulty faced by families in complying with antiepileptic drug treatment in pediatric patients is that the patient does not like the taste of the drug. This has shown that it is necessary to develop new pharmaceutical technologies for the taste of antiepileptic drugs. We think that it would be beneficial to carry out drug taste studies, especially with drugs that are not liked in general, such as antiepileptics, in large series using the flavors added to the drugs, the type, number and amount of auxiliary or sweeteners standardized and using comparable preparations that are identical in this respect, in the same physical structure.

Keywords: Epilepsy; medication adherence; anticonvulsants
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