Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Choroidal Thickness in the Primary Open-Angle Glaucoma and Evaluation of the Association with Visual Field Damage: Case Control Study
Primer Açık Açılı Glokomda Koroid Kalınlığının Ölçülmesi ve Görme Alanı Hasarı ile İlişkisinin Değerlendirilmesi: Vaka Kontrol Çalışması
Veysi YILDIZa, Tekin YAŞARb
aClinic of Ophthalmology, Batman Training and Research Hospital, Batman, Türkiye
bDepartment of Ophthalmology, University of Health Sciences Beyoğlu Eye Training and Research Hospital, İstanbul, Türkiye
Turkiye Klinikleri J Ophthalmol. 2022;31(4):207-15
doi: 10.5336/ophthal.2021-87408
Article Language: EN
Full Text
ABSTRACT
Objective: To measure the macular and peripapillary choroidal thickness in the primary open-angle glaucoma (POAG), and to investigate the association between the visual field loss and choroidal thickness. Material and Methods: The study enrolled 90 eyes of 50 patients diagnosed with POAG, and 30 eyes of 19 patients as the control group (Group 0). Patients with POAG were divided into 3 groups as mild (Group 1), moderate (Group 2), and severe (Group 3) according to Hodapp, Anderson, Parrish criteria and 30 eyes were included in each group. The macular and peripapillary choroidal thicknesses were compared between the groups through enhanced depth imaging spectral-domain optic coherence tomography. Visual fields were measured by automated perimetry. Results: The peripapillary choroidal thickness in Group 3 with severe glaucomatous injury was significantly thinner when compared with the control group at all peripapillary locations except nasal location. Furthermore, the peripapillary choroidal thickness in Group 3 was significantly thinner than Group 1 at the mean, temporal, superior, superonasal, and inferonasal locations. Macular choroidal thickness did not differ between the groups. The age was inversely correlated with macular and peripapillary choroidal thickness. Conclusion: The peripapillary choroidal thickness was thinner in eyes with severe glaucomatous damage compared to normal and mildly glaucomatous damaged eyes. Treatments that support choroidal circulation may be beneficial in cases with severe POAG.

Keywords: Choroidal thickness; primary open-angle glaucoma; visual field; enhanced depth imaging optical coherence tomography; mean deviation
ÖZET
Amaç: Bu çalışmanın amacı, primer açık açılı glokomda (PAAG) makular ve peripapiller koroid kalınlığının ölçülerek görme alanı kaybı ile koroid kalınlığı arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya her grupta toplam 30 göz olacak şekilde PAAG tanılı 50 hastanın 90 gözü ve kontrol grubu (Grup 0) olarak 19 hastanın 30 gözü dâhil edildi. PAAG'li hastalar Hodapp, Anderson, Parrish kriterlerine göre hafif (Grup 1), orta (Grup 2) ve ağır (Grup 3) görme alanı kaybı olmak üzere 3 gruba ayrıldı ve her gruba 30 göz dâhil edildi. Gruplar arasında ve kontrol grubunda makular ve peripapiller koroid kalınlığı geliştirilmiş derinlik görüntüleme spektral domain optik koherens tomografi ile ölçülerek karşılaştırıldı. Görme alanları otomatik perimetri ile ölçüldü. Bulgular: Ağır glokomatöz hasar olan Grup 3'te peripapiller koroid kalınlığı kontrol grubuna göre nazal lokalizasyon haricindeki tüm peripapiller lokalizasyonlarda anlamlı derecede ince bulundu. Yine Grup 3'te peripapiller koroid kalınlığı Grup 1'e göre ortalama, temporal, superior, superonazal ve inferonazal lokalizasyonlarda anlamlı derecede ince bulundu. Makular bölgeden yapılan koroid kalınlık ölçümlerinde gruplar arasında anlamlı farklılık bulunmadı. Yaşın makular ve peripapiller koroid kalınlığı ile negatif korele olduğu görüldü. Sonuç: Peripapiller koroid kalınlığı ağır glokomatöz hasar olan gözlerde normal ve hafif glokomatöz hasarlı gözlere göre incelmektedir. Şiddetli PAAG'li olgularda koroid dolaşımını destekleyen tedaviler faydalı olabilir.

Anahtar Kelimeler: Koroid kalınlığı; primer açık açılı glokom; görme alanı; geliştirilmiş derinlik görüntüleme optik koherens tomografi; ortalama deviasyon
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