Journal of Thoracic Oncology

.: ORIGINAL RESEARCH
Bir Göğüs Cerrahı Lenf Nodu Metastazlarını Ameliyat Esnasında Lenf Nodunun Boyutuna Bakarak Tespit Edebilir mi?
Bir Göğüs Cerrahı Lenf Nodu Metastazlarını Ameliyat Esnasında Lenf Nodunun Boyutuna Bakarak Tespit Edebilir mi?
Ryuichi Suemitsu, MD, PhD, * Sadanori Takeo, MD, PhD, * Hironori Matsuzawa, MD, * Masafumi Yamaguchi, MD, PhD, * Seiya Momosaki, MD, PhD, † and Noriko Uesugi, MD, PhD†
Departments of *Thoracic Surgery and †Pathology, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.
Article Language: TR
ÖZET
Amaç: Metastatik bir lenf nodunda sıklıkla boyut artışı olmaktadır; fakat doğrudan doğruya lenf nodlarının boyutu ve klinikopatolojik özellikleri konusunda sınırlı veri bulunmaktadır. Metotlar: Akciğer kanseri nedeni ile lenf nodu diseksiyonu ile birlikte pulmoner rezeksiyon geçirmiş olan 454 hastadan diseke edilen olan toplam 848 metastatik ve 10.462 adet metastatik olmayan lenf nodu boyutu sayısal olarak belirlendi. Sonuçlar: Metastatik lenf nodlarının kısa ekseni ve hacmi anlamlı olarak metastatik olmayanlardan daha büyüktü. Lenf nodu ne kadar küçükse metastatik olma sıklığı da o kadar azdı; fakat adenokarsinom ve skuamöz hücreli karsinomların sıralamada beşinci en büyük lenf nodundan daha küçük olanların metastatik olma oranı sırasıyla adenokarsinomda %21.8 ile skuamöz hücreli karsinomda %26.2 idi. Hiler ve mediastinal lenf nodu istasyonları ortak olarak incelendiğinde, akciğer kanseri hastalarının %1.14 ila %4'ü en büyük ve ikinci büyük lenf nodunda metastaz olmamasına karşın küçük nodlarda metastaza sahipti. Tartışma: Özellikle adenokarsinom hastalarında, hiler ve mediastinal istasyonlarda bulunan küçük lenf nodları, en büyük ve ikinci büyük lenf nodu metastaz yönünden negatif olsa bile sıklıkla karsinom metastazına sahiptir. Bu nedenle cerrahi onkologlar, akciğer kanserinin pulmoner rezeksiyonu sırasında örnekleme değil sistemik lenf nodu diseksiyonu yapmalıdırlar.

Anahtar Kelimeler: Akciğer kanseri, Metastaz, Lenf nodu.
ABSTRACT
Objective: A metastatic lymph node commonly becomes enlarge; however, there is limited data available with regard to the direct measurement of lymph nodes and their clinicopathologic characteristics. Methods: The size of dissected lymph node was quantified in a total of 848 nodes with metastasis and 10,462 nodes without metastasis from 454 patients with lung cancer who underwent a pulmonary resection with lymph node dissection. Results: The short axis and the volume of the metastatic lymph nodes were significantly greater than those of the nonmetastatic ones. The smaller the lymph node, the less frequently the lymph nodes were metastatic; however, the ratios of nodes smaller than the fifth largest lymph node with metastasis of adenocarcinoma and squamous cell carcinoma were 21.8 to 26.2%, respectively. When the hilar and mediastinal lymph node stations were examined, 1.14 to 4.00% of the lung cancer patients had lymph node metastasis in small lymph node despite having no metastases in the largest and second largest lymph nodes. Conclusions: The small lymph nodes in the hilar or mediastinal stations frequently had metastases of carcinoma even though largest and second largest lymph nodes were negative for metastases, especially in adenocarcinoma cases. Surgical oncologists should, therefore, perform systemic lymph node dissection, and not sampling, during a pulmonary resection of lung cancer.

Keywords: Lung cancer, Metastasis, Lymph node.

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30.03.2014

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