Journal of Reconstructive Urology

.: ORIGINAL RESEARCH
Association Between Erectile Dysfunction and Fontaine Classification in Patients with Peripheral Artery Diseases: A Cross Sectional Study
Periferik Arter Hastalığı Olan Hastalarda Fontaine Sınıflaması ve Erektil Disfonksiyon Arasındaki İlişki: Kesitsel Çalışma
Hakkı Kürşat ÇETİNa, Ufuk ÇAĞLARb, Ali AYRANCIb, Hüseyin Burak YAZILIb, Ömer SARILARb, Tolga DEMİRa, Faruk ÖZGÖRb
aClinic of Cardiovascular Surgery, SBÜ Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye
bClinic of Urology, Haseki Training and Research Hospital, İstanbul, Türkiye
J Reconstr Urol. 2022;12(3):114-9
doi: 10.5336/urology.2022-92776
Article Language: EN
Full Text
ABSTRACT
 Objective: To identify the association between peripheral artery disease (PAD) and erectile dysfunction (ED) with using Fontaine classification (FC). Material and Methods: The present study was planned in a prospective manner between November 2020- April 2022, and male patients who admitted to cardiovascular surgery outpatient polyclinic were enrolled into the study. Severity of PAD and presence of ED were evaluated by FC and International Index of Erectile Function (IIEF) score, respectively. To clarify the correlation between ED and FC, patients were divided into 2 groups. Patients with IIEF score ≤11 were classified as Group 1 and patients with IIEF score ≥17 were categorized as Group 2. The groups were compared in terms of patient demographic characteristics, blood test outcomes, IIEF scores and GS scores. Results: Totally, 181 patients with mean age 55.9 years were enrolled in the study. Smoking rate and presence of diabetes mellitus was significantly lower in favor of patients without ED (69.1% vs 42.5%, p=0.001 and 54.4% vs 33.6%, p=0.006).Lower extremity ischemic scores according to FC were significantly better in favor of patients without ED (p=0.001). Multivariate regression analysis showed that higher body mass index (BMI), being a smoker and presence of diabetes mellitus were predictive factors for ED (p=0.001,p=0.034 and p=0.001, respectively). In addition, FC 3-4 were significantly associated with ED (7.132 times, p=0.001). Conclusion: The present study revealed for the first time that FC 3-4 increased risk of ED. Additionally, diabetes mellitus, smoking history, and higher BMI were predictive factors for ED.

Keywords: Body mass index; erectile dysfunction; low density lipoprotein; peripheral arterial disease
ÖZET
 Amaç: Fontaine sınıflandırmasını (FS) kullanarak periferik arter hastalığı (PAH) ve erektil disfonksiyon (ED) arasındaki ilişkiyi belirlemektir. Gereç ve Yöntemler: Bu çalışma, Kasım 2020-Nisan 2022 tarihleri arasında prospektif olarak planlanmış ve kardiyovasküler cerrahi polikliniğine başvuran erkek hastalar çalışmaya dâhil edilmiştir. PAH şiddeti ve ED varlığı sırasıyla FS ve Uluslararası Erektil Fonksiyon İndeksi [International Index of Erectile Function (IIEF)] skoru ile değerlendirildi. IIEF skoru ≤11 olan hastalar Grup 1, IIEF skoru ≥17 olan hastalar Grup 2 olarak sınıflandırıldı. Gruplar, hasta demografik özellikleri, kan testi sonuçları, IIEF skorları ve FS skorları açısından karşılaştırıldı. Bulgular: Çalışmaya, yaş ortalaması 55,9 yıl olan 181 hasta dâhil edildi. Sigara içme oranı ve diabetes mellitus varlığı, ED'si olmayan hastalar lehine anlamlı olarak daha düşüktü (%69,1'e karşı %42,5, p=0,001 ve %54,4'e karşı %33,6, p=0,006). Ortalama düşük yoğunluklu lipoprotein seviyesi, ED'li hastalarda daha yüksekti (p=0,012). FS'ye göre alt ekstremite iskemik skorları ED'si olmayan hastalar lehine anlamlı olarak daha iyiydi (p=0,001). Çok değişkenli regresyon analizi, yüksek beden kitle indeksi (BKİ), sigara kullanımı ve diabetes mellitus varlığının ED için öngörücü faktörler olduğunu gösterdi (p=0,001, p=0,034 ve p=0,001, sırasıyla). Ayrıca FS 3- 4, ED ile anlamlı olarak ilişkiliydi (7.132 kez, p=0,001). Sonuç: Bu çalışma, ilk kez FS 3-4'ün ED riskini artırdığını ortaya koydu. Ek olarak, diabetes mellitus varlığı, sigara içme öyküsü ve daha yüksek BKİ, ED için öngörücü faktörlerdi.

Anahtar Kelimeler: Beden kitle indeksi; erektil disfonksiyon; düşük yoğunluklu lipoprotein; periferik arter hastalığı
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