Objective: Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss. Some biomarkers and clinical severity scores have been described for AA; however, a simple and inexpensive marker that correlates with disease activity may provide a more practical management strategy. The aim of the present study was to evaluate the serum mean platelet volume (MPV), platelet count (PC), and MPV/PC ratio in patients with AA and assess their association with disease activity and severity. Material and Methods: This retrospective study included 75 adult patients diagnosed with AA and 70 healthy controls. The white blood cell count, red blood cell count, hemoglobin, hematocrit, MPV, PC, and MPV/PC ratio were compared between the two groups. In addition, the same parameters were compared between the active and inactive; severe and mild/moderate; and acute and chronic AA subgroups. Results: The PC and MPV values were significantly lower and the MPV/PC ratio significantly higher in the AA group (p0.05). The PC was significantly lower in active and severe disease (p>0.05). Conversely, the MPV/PC ratio was significantly higher in the active and severe group as compared with that in the inactive and mild/moderate group (p>0.05). The cut-off value for the MPV/PC ratio was 0.036, with a sensitivity of 52.0% and a specificity of 85.7%. Conclusion: Based on our study findings, the MPV/PC ratio may be a useful tool for the practical assessment of disease activity in AA.
Keywords: Alopecia areata; mean platelet volume; platelet; ratio
Amaç: Alopesi areata (AA), skarsız saç dökülmesi ile karakterize otoimmün bir hastalıktır. AA'da bazı biyobelirteç ve klinik şiddet skorları tanımlanmıştır, ancak hastalık aktivitesi ile ilişkili olan basit ve ucuz bir belirteç daha pratik bir tedavi yönetimi sağlayabilir. Bu çalışmanın amacı, AA hastalarında serum ortalama trombosit hacmi (OTH), trombosit sayısı (TS) ve OTH/TS oranını ve bunların hastalık aktivitesi ve şiddeti ile ilişkisini değerlendirmektir. Gereç ve Yöntemler: Bu retrospektif çalışma, AA tanısı almış 75 erişkin hasta ve 70 sağlıklı kontrolü içermektedir. Beyaz kan hücresi, hemoglobin, kırmızı kan hücresi, hematokrit, OTH, TS, OTH/TS parametreleri 2 grup arasında karşılaştırıldı. Ek olarak aynı parametreler; aktif ve inaktif, şiddetli ve hafif/orta, akut ve kronik AA alt grupları arasında karşılaştırıldı. Bulgular: AA grubunda TS ve OTH değerleri istatistiksel olarak anlamlı oranda düşüktü ve OTH/TS oranı anlamlı olarak yüksekti (sırasıyla p0,05). TS, aktif ve şiddetli hastalıkta istatistiksel olarak anlamlı oranda daha düşüktü (p>0,05). Tersine OTH/TS oranı, aktif ve ağır grupta inaktif ve hafif/orta şiddete göre istatistiksel olarak anlamlı oranda daha yüksekti (p>0,05). OTH/TS oranının kesme değeri 0,036; duyarlılık %52,0 ve özgüllük %85,7 idi. Sonuç: Çalışma bulgularına dayanarak, OTH/TS oranı, AA'daki hastalık aktivitesinin pratik değerlendirmesi için yararlı bir araç olabilir.
Anahtar Kelimeler: Alopesi areata; ortalama trombosit hacmi; platelet; oran
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