Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Assessment of Serum Creatinine, Cystatin C and Neutrophil Gelatinase-associated Lipocalin Levels in Rosacea: A Case-Control Study
Rozasea Hastalarında Serum Kreatinin, Sistatin C ve Nötrofil Jelatinaz İlişkili Lipokalin Düzeylerinin Değerlendirilmesi: Bir Vaka-Kontrol Çalışması
Ezgi AKTAŞ KARABAYa, Emre KARABAYb, Özlem UNAY DEMİRELc, Nejdet KARŞIYAKALId
aBahçeşehir University Faculty of Medicine, Department of Dermatology and Venereology, İstanbul, TURKEY
bHaydarpaşa Numune Training and Research Hospital, Department of Urology, İstanbul, TURKEY
cBahçeşehir University Faculty of Medicine, Department of Biochemistry, İstanbul, TURKEY
dAcıbadem Hospital, Department of Urology, İstanbul, TURKEY
Turkiye Klinikleri J Dermatol. 2020;30(2):49-55
doi: 10.5336/dermato.2020-75109
Article Language: EN
Full Text
ABSTRACT
 Objective: Rosacea, a chronic inflammatory skin disease, is known to be associated with various systemic disorders. However, limited data are available on the association between rosacea and renal diseases. The objective of this study was to evaluate serum creatinine, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) levels in patients with rosacea without any systemic diseases. Material and Methods: A prospective, case-control study was planned to investigate the relationship between rosacea and renal involvement by evaluating serum creatinine, cystatin C and NGAL levels. Results: A total of 38 patients with rosacea and 45 healthy controls were included. Statistically significant differences in serum creatinine and cystatin C levels were noted between the patient and control groups (respectively p=0.012, p<0.001). No statistically significant difference was shown in the values of NGAL between the two groups (p=0.235). A positive correlation was noted between serum creatinine and serum cystatin C levels (r=0.434; p<0.001). The serum levels of cystatin C were positively correlated with disease duration (r=0.511, p<0.001). Conclusion: Serum creatinine and cystatin C levels may provide early detection of renal dysfunction in rosacea.

Keywords: Creatinine; cystatin C; inflammation; neutrophil gelatin ase-associated lipocalin; renal disease; rosacea
ÖZET
 Amaç: Rozasea, pek çok sistemik hastalıkla ilişkili olduğu bilinen kronik, inflamatuar bir deri hastalığıdır. Bununla birlikte rozasea ve renal hastalıklar arasındaki ilişkiyle ilgili bilgi sınırlıdır. Bu çalışmanın amacı, hiçbir sistemik hastalığı olmayan rozasea hastalarında, serum kreatinin, sistatin C ve nötrofil jelatinaz ilişkili lipokalin (NGAL) düzeylerini değerlendirmektir. Gereç ve Yöntemler: Rozasea ve renal tutulum arasındaki ilişkiyi araştırmak için serum kreatinin, sistatin C ve NGAL düzeylerini değerlendiren prospektif, vaka-kontrollü çalışma planlanmıştır. Bulgular: Toplam 38 rozasea hastası ve 45 sağlıklı kontrol çalışmaya dâhil edilmiştir. Serum kreatinin ve sistatin C düzeylerinde hasta ve kontrol grubu arasında istatistiksel olarak anlamlı fark bulunmuştur (sırasıyla p=0,012, p<0,001). NGAL değerlerinde, 2 grup arasında anlamlı bir fark bulunmamıştır (p=0,235). Serum kreatinin ve serum sistatin C düzeyleri arasında pozitif bir korelasyon izlenmiştir (r=0,434; p<0,001). Serum sistatin C düzeyleri hastalık süresiyle pozitif korelasyon göstermiştir (r=0,511, p<0,001). Sonuç: Serum kreatinin ve sistatin C düzeyleri rozasea hastalarında renal disfonksiyonun erken bir belirteci olabilir.

Anahtar Kelimeler: Kreatinin; sistatin C; inflamasyon; nötrofil jelatinaz ilişkili lipokalin; renal hastalık; rozasea
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