Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Aralıklı Oruç ve Bazı Hastalıklar Üzerine Etkileri
Intermittent Fasting and Its Effects on Some Diseases
Seda Nur KÖKTÜRKa, Hülya YARDIMCIa
aAnkara Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, TÜRKİYE
Turkiye Klinikleri J Health Sci. 2021;6(4):949-57
doi: 10.5336/healthsci.2020-80090
Article Language: TR
Full Text
ÖZET
 Beslenme ve sağlık, birbirinden ayrılmaz bir bütündür. Ayrıca bireylerin diyete uyumu, diyetin içeriğinden daha fazla önem taşımaktadır. Aralıklı oruç, çeşitli protokollere sahip olan ve temelde komple aralıklı oruç, modifiye edilmiş aralıklı oruç, zaman kısıtlı aralıklı oruç ve Buchinger oruç periyodu olmak üzere 4 başlıkta incelenen bir diyet modelidir. Başlangıçta artan obezite prevalansına yönelik obez bireylerde vücut ağırlığı kaybı stratejisi olarak uygulanan alternatif bir diyet yöntemi olarak ortaya çıkmış olsa da aralıklı orucun, klinik öncesi ve klinik çalışmalarda çeşitli metabolik yollarla glukoz, lipid, protein metabolizmasını etkilemesinin yanı sıra sirkadiyen ritim, oksidatif stres, inflamasyon gibi faktörleri de etkileyerek diyabet, kardiyovasküler hastalıklar, nörolojik hastalıklar ve kanser gibi çeşitli hastalıklarda olumlu etkiler sağladığı ve bunun yanında aralıklı oruç protokolünü uygulayan bireylerin diyete uyumunun, günlük enerji kısıtlaması içeren diyetlere uyumu ile benzer olduğu gösterilmiştir. Bu derlemede; farklı aralıklı oruç modellerinin çeşitli hastalık durumlarında oynadığı rollerin ele alınması amacıyla güncel literatürün taranarak özetlenmesi amaçlanmıştır. Literatürdeki bilgiler ışığında, sağlıklı beslenme ilkelerinden uzaklaşmadan uygulanan aralıklı orucun, profilaktik veya terapötik olumlu etkilere sahip olabileceği düşünülebilir fakat insanlara yönelik çalışmalar, çoğunlukla fazla kilolu ve obez erişkin bireylerle yürütüldüğü için aralıklı oruç protokollerinin her yaş grubunda uygulanmasının güvenli olup olmadığı tartışmalıdır. Ayrıca literatürde, birçok aralıklı oruç protokolünün yer alması ve oruç protokollerinin standartlaştırılamamış olması önemli bir sorundur. Daha net ve kesin sonuçlar için bu konuda daha fazla çalışma yapılmasına ihtiyaç vardır.

Anahtar Kelimeler: Aralıklı oruç; perhiz; diyet; diyet tedavisi; obezite
ABSTRACT
 Nutrition and health are inseparable from each other. In addition, compliance with the diet is more important than the content of the diet. Intermittent fasting is a diet model that has various protocols and is mainly examined under four headings: complete intermittent fasting, modified intermittent fasting, time-limited intermittent fasting, and Buchinger fasting period. Although it initially emerged as an alternative diet method applied as a weight loss strategy in obese individuals for increasing obesity prevalence, it affects glucose, lipid and protein metabolism through various metabolic pathways, as well as by affecting factors such as circadian rhythm, oxidative stress, inflammation in preclinical and clinical studies. It has been shown that it provides positive effects in various diseases such as diabetes, cardiovascular diseases, neurological diseases and cancer, and that the compliance of individuals who follow the intermittent fasting protocol is similar to their compliance with diets containing daily energy restriction. In this review; it is aimed to summarize the current literature by reviewing the roles of various intermittent fasting models in health and illness. In the light of the information in the literature, it can be thought that intermittent fasting applied without departing from the principles of healthy eating may have prophylactic or therapeutic positive effects, but it is controversial whether intermittent fasting is safe in all age groups since intervention studies on humans are mostly conducted with overweight and obese adults. More studies are needed on this subject for clearer and more precise results.

Keywords: Intermittent fasting; fasting; diet; diet therapy; obesity
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www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com