Journal of Literature Pharmacy Sciences

Aralıklı Oruç Kavramının Moleküler ve Hücresel Temelleri: Geleneksel Derleme
Molecular and Cellular Basics of Intermittent Fasting: Traditional Review
Melike ÖZDERa , Yüce ERÇETİNb, Hasan AKBABAb
aEge Üniversitesi Eczacılık Fakültesi, Doktora Programı, İzmir, Türkiye
bEge Üniversitesi Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Biyoteknoloji ABD, İzmir, Türkiye
J Lit Pharm Sci. 2023;12(2):123-34
doi: 10.5336/pharmsci.2022-94991
Article Language: TR
Full Text
ÖZET
 İçinde bulunduğumuz sanayi, bilgi, teknoloji ve internet çağı insanlar için büyük konfor ve kolaylıklar sağlamaktadır. Bu konforla gelen yaşam tarzı ve yaşam standartları değişiklikleri, geçtiğimiz dönemlere göre daha uzun yaşam süresi gibi belirgin farklılıklar göstermesine karşılık obezite, diyabet, Alzheimer gibi rahatsızlıkları da beraberinde getirmiştir. Günümüzün gelişmiş sağlık teknolojisinin verdiği avantajlar ile insanlık, yaşam kalitesini artırmanın ve hastalıklardan kaçınmanın yollarını aramaktadır. Bu derleme, bunlardan biri olan ve günümüzde gittikçe popülerleşen aralıklı oruç kavramının tanımını, aralıklı orucun tiplerini, bu kavram ile ilişkili ögeleri, aralıklı orucun çeşitli hastalıkların patofizyolojsine etkisini, yapılan preklinik ve klinik deneyleri ile moleküler ve hücresel düzeyde ele almaktadır. Aralıklı oruç kavramı, birkaç saatten birkaç güne kadar süren ve bu süre zarfında çok az veya hiç kalori tüketilmeyen farklı beslenme rejimlerinin adı olarak tanımlanmaktadır. Bu çalışmada aralıklı oruç, otofaji, sirkadiyen ritim, moleküler mekanizmalar ve hücresel yollar başlıkları altında ele alınmıştır. Aralıklı orucun rolü, kanser, kardiyovasküler hastalıklar, yaşlanma, beyin fonksiyonları, obezite ve diyabet gibi hastalıklar için değerlendirilmiştir. Aralıklı oruç diyetlerine tabi tutulanlarda sağlık göstergelerinin olumlu yönde etkilendiği ve hastalıkları önleme veya tedavi etme bağlamında umut verici sonuçlar sunduğu, moleküler mekanizmalar ile ilişkilendirilerek aktarılmıştır. Aralıklı orucun profilaktik veya terapötik yaklaşımlarda uygun maliyetli ve düşük yan etkili bir destekleyici mekanizma olduğu ortaya konmuştur.

Anahtar Kelimeler: Kalori kısıtlaması; aralıklı oruç; otofaji; sirkadiyen ritim
ABSTRACT
 The industry, information, technology, and internet age that we are in provide great comfort and convenience for people. The lifestyle and living standards of the past century show distinct differences, such as longer life expectancy compared to previous periods. These differences have brought along diseases such as obesity, diabetes, and Alzheimer's disease. With the advantages of today's advanced health technology, humanity has sought ways to increase the quality of life and avoid diseases. This study deals with the definition of the concept of intermittent fasting -which is becoming increasingly popular today- the types of intermittent fasting, the elements associated with this concept, and the effect of intermittent fasting on the pathophysiology of various diseases including clinical, molecular, and cellular levels with the clinical and pre-clinical trials. The concept of intermittent fasting is defined as the name of different types of eating regimes that last from a few hours to a few days, in which little or no calories are consumed. Intermittent fasting has been discussed under the headings of autophagy, circadian rhythm, molecular mechanisms, and cellular pathways. The role of intermittent fasting has been evaluated for diseases such as cancer, cardiovascular diseases, aging, brain functions, obesity, and diabetes. It has been reported that intermittent fasting diets positively affect health indicators that subjected to intermittent fasting diets and offer promising results in the context of preventing or treating diseases, in relation to molecular mechanisms. Intermittent fasting has been shown to be a cost-effective and low sideeffect supportive mechanism in prophylactic or therapeutic approaches.

Keywords: Caloric restriction; intermittent fasting; autophagy; circadian rhythm
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7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com