Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Anogenital Verrukaların Klinik, Patolojik ve Prognostik Özelliklerinin İncelenmesi: Retrospektif Analiz
Retrospective Evaluation of Clinic, Pathologic and Prognostic Characteristics of Anogenital Warts
Işıl Göğem İMRENa , Şule GÖKŞİNb , Sevilay ERTÜRKb , Neşe ÇALLI DEMİRKANc , Şeniz DUYGULUb
aDenizli Devlet Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, Denizli, Türkiye
bPamukkale Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıkları ABD, Denizli, Türkiye
cPamukkale Üniversitesi Tıp Fakültesi, Tıbbi Patoloji ABD, Denizli, Türkiye
Turkiye Klinikleri J Dermatol. 2024;34(1):22-31
doi: 10.5336/dermato.2023-100350
Article Language: TR
Full Text
ÖZET
 Amaç: Kliniğimizde takip ve tedavi edilen erişkin anogenital verruka olgularının demografik, klinik, patolojik ve prognostik özelliklerini inceleyip ülkemize dair güncel verileri ortaya koyarak, değişken dinamikleri olan bu hastalığın yönetimine katkı sunmayı amaçladık. Gereç ve Yöntemler: Bu kesitsel çalışmada, polikliniğimizde 2015-2021 yılları arasında, anogenital verruka tanısıyla takip edilen 18 yaş ve üzeri 329 hastanın klinik ve epidemiyolojik verileri retrospektif olarak değerlendirilmiştir. Bulgular: Çalışmaya dâhil edilen 329 hastanın %78,4'ü erkek, %21,6'sı kadın, ortalama yaş 35,2 (± 12,1) medyan yaş 32 (aralık 18-7) idi. En çok hasta 124 (%37,7) hasta ile 18-30 yaş aralığında bulunmaktaydı. Hastaların %10'unda ekstragenital verruka tespit edildi. Hiçbir hastada insan bağışıklık yetersizliği virüsü testi pozitif bulunmazken, 1 hastada VDRL, 3 hastada hepatit B yüzey antijeni, 4 hastada anti-hepatit C virüsü pozitif olarak saptandı. Lezyonlarından histopatolojik inceleme yapılan 27 hastanın 19'unda verruka ile uyumlu bulgulara rastlanırken, 3 hastada displazi, 5 hastada neoplazi tespit edilmiştir. Bir yıllık düzenli tedavinin sonucunda, hastaların %74,2'sinde gözle görünür verruka lezyonu kalmazken, %2,7'sinde tedavilere direnç, %0,9'unda kısmi cevap, %21,6'sında ilk 1 yıl içinde rekürrens gözlenmiştir. Sonuç: Sağlık kuruluşlarına zamanında başvuru, uygun tedavinin erken dönemde düzenlenmesi, düzenli takip ile malignite gibi ciddi komplikasyonların yaratacağı morbidite ve mortalitenin azaltılabileceğine inanmaktayız.

Anahtar Kelimeler: İnsan papilloma virüs; anogenital verruka; epidemiyoloji
ABSTRACT
 Objective: We aimed to contribute to the management of this disease with variable dynamics by examining the demographic, clinical, pathologic and prognostic features of the adult anogenital verruca cases followed and treated in our clinic, presenting current data for our country. Material and Methods: In this cross-sectional study, we retrospectively evaluated clinical and demographic data of 329 patients aged 18 years and older who were followed up with a diagnosis of anogenital verruca at our clinic between 2015 and 2021. Results: Of the 329 patients included in the study, 78.4% were male and 21.6% were female, with a mean age of 35.2 (± 12.1) and a median age of 32 (range 18-7). The majority of patients were between 18 and 30 years of age, with 124 (37.7%) patients. Extragenital verrucae were detected in 10% of the patients. There was no positive case of anti-human immunodeficiency virus, however, Venereal Disease Research Laboratory positivity in 1 patient, hepatitis B surface antigen positivity in 3 patients and antihepatitis C virus positivity in 4 patients were detected. Histopathologic examination was performed in 27 patients, verruca vulgaris was detected in 19 patients, dysplasia in 3 patients and neoplasia in 5 patients. After one year of regular treatment, 74.2% of patients had no visible verruca lesion, 2.7% were resistant to treatment, 0.9% had a partial response, and 21.6% had a recurrence within the first year. Conclusion: We believe that morbidity and mortality from serious complications such as malignancy can be reduced through timely presentation to healthcare facilities, early initiation of appropriate treatment, and regular follow-up.

Keywords: Human papillomavirus; anogenital wart; epidemiology
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