Turkiye Klinikleri Journal of Pediatrics

.: ORIGINAL RESEARCH
Analysis of the Relation Between the Systemic and Ocular Oxidative Stress in Pediatric Patients with Idiopathic Congenital Cataracts: A Cross-Sectional Study
İdiyopatik Konjenital Kataraktı Olan Pediatrik Hastalarda Sistemik ve Oküler Oksidatif Stres Arasındaki İlişkinin İncelenmesi: Kesitsel Çalışma
Ali Mert KOÇERa, Zeynep ADIYAMAN KOÇERb , Çiğdem ÜLKÜ CANc, Mehmet ŞENEŞd, Gizem YILMAZ ÇALIKd, Eyüpcan ŞENSOYc, Sibel POLATc
aClinic of Ophthalmology, Arnavutköy State Hospital, İstanbul, Türkiye
bClinic of Medical Biochemistry, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye
cClinic of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Türkiye
dClinic of Medical Biochemistry, Ankara Training and Research Hospital, Ankara, Türkiye
Turkiye Klinikleri J Pediatr. 2022;31(3):143-50
doi: 10.5336/pediatr.2021-87606
Article Language: EN
Full Text
ABSTRACT
 Objective: To investigate the systemic and ocular oxidant-antioxidant status of pediatric patients with idiopathic congenital cataracts. Material and Methods: This study investigated the serum and aqueous humor samples of 18 cases with idiopathic congenital cataract and the serum samples of 20 age-and sex-matched healthy cases. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol (T-SH), and thiobarbituric acid reactive substances (TBARS) levels in serum and aqueous humor samples were evaluated using spectrophotometric and spectrofluorometric methods. The weight, height, and body mass index parameters were recorded. Results: Study groups had statistically similar serum TAS, TOS, OSI, T-SH, and TBARS levels (p˃0.05). Statistically significant correlations between oxidant-antioxidant status in serum and aqueous humor were not detected in the patient group (p˃0.05). There was a statistically significant positive correlation was observed between the axial length and aqueous humor T-SH levels (r=0.651, p=0.042). Additionally, statistically significant positive correlation was observed between the age and serum TBARS levels in the patient group (r=0.422, p=0.008). Conclusion: In terms of oxidant-antioxidant status, this study did not find a correlation between serum and aqueous humor samples in pediatric patients with idiopathic congenital cataract and no difference in serum samples between study groups. This study suggests that oxidative stress may not be a part of idiopathic cataract development in the pediatric population.

Keywords: Antioxidant; aqueous humor; cataract; oxidant
ÖZET
 Amaç: İdiyopatik konjenital kataraktı olan pediatrik hastalarda, sistemik ve oküler oksidan-antioksidan seviyelerinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada, idiyopatik konjenital kataraktı olan 18 olgunun serum ve hümor aköz örnekleri ile yaş ve cinsiyet uyumlu 20 sağlıklı olgunun serum örnekleri incelenmiştir. Serum ve hümor aköz örneklerindeki total antioksidan seviye (TAS), total oksidan seviye (TOS), oksidatif stres indeksi (OSI), total tiyol (TSH) ve tiyobarbitürik asit reaktif maddeleri [thiobarbituric acid reactive substances (TBARS)] düzeyleri spektrofotometrik ve spektroflorimetrik yöntemler kullanılarak ölçüldü. Boy, kilo ve vücut kitle endeksi değerleri kaydedildi. Bulgular: Çalışma grupları arasında, istatistiksel olarak benzer serum TAS, TOS, OSI, T-SH ve TBARS düzeyleri saptandı (p˃0,05). Hasta grubunda, serum ve hümor aköz oksidan-antioksidan seviyeleri arasında istatistiksel olarak anlamlı herhangi bir korelasyon saptanmadı (p˃0,05). Aksiyel uzunluk ve hümor aköz T-SH düzeyleri arasında istatistiksel olarak anlamlı pozitif korelasyon izlendi (r=0,651, p=0,042). Ayrıca hasta grubunda serum TBARS düzeyleri ile yaş arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (r=0,422, p=0,008). Sonuç: Bu çalışmada, idiyopatik konjenital kataraktı olan pediatrik hastalardaki serum ve hümor aköz oksidan-antioksidan seviyeleri için herhangi bir korelasyon saptanmadı. Ayrıca çalışma grupları arasında, serum oksidan-antioksidan seviyeleri açısından herhangi bir farklılık görülmedi. Bu çalışma, pediatrik popülasyonda oksidatif stresin idiyopatik katarakt gelişimi için önemli bir etkisi olmayabileceğini düşündürmektedir.

Anahtar Kelimeler: Antioksidan; hümor aköz; katarakt; oksidan
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