Turkiye Klinikleri Journal of Pediatrics

.: ORIGINAL RESEARCH
Ailesel Akdeniz Ateşi Olan Çocuklarda Ortalama Trombosit Hacminin Klinik Önemi
Clinical Importance of Mean Platelet Volume in Children with Familial Mediterranean Fever
Dilek KONUKSEVERa, Esra BASKINb, Kaan Savaş GÜLLEROĞLUb, Betül ORHAN KILIÇc
aAnkara Bilkent Şehir Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Ankara, TÜRKİYE
bBaşkent Üniversitesi Tıp Fakültesi, Çocuk Nefroloji BD, Ankara, TÜRKİYE
cBaşkent Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları ABD, Ankara, TÜRKİYE
Turkiye Klinikleri J Pediatr. 2021;30(3):212-8
doi: 10.5336/pediatr.2021-81360
Article Language: TR
Full Text
ÖZET
 Amaç: Ortalama trombosit hacminin (OTH), inflamatuar hastalıkların da dâhil olduğu birçok kronik hastalıkta belirteç olarak kullanılabileceği gösterilmiştir. Çalışmamızda, Ailesel Akdeniz Ateşi (AAA) olan çocuklarda; hastalık şiddeti, genetik mutasyon türü, atak/ataksız dönemlerin, OTH düzeyleri ile ilişkisini incelemeyi planladık. Gereç ve Yöntemler: Çalışmaya, Tel-Hashomer tanı kriterlerine göre AAA tanısı almış 109 çocuk dâhil edildi. Hastalar, Pras skorlama sistemine göre sınıflandırıldı. Hastaların demografik özellikleri, genetik tarama sonuçları, başvuru şikâyetleri ile tam kan sayımı parametreleri, OTH düzeyleri, biyokimyasal testleri, proteinüri miktarları, fibrinojen, eritrosit sedimantasyon hızı, C-reaktif protein değerleri, ataklı ve ataksız dönemlerine göre ayrı ayrı kaydedildi. Bulgular: Çalışmamıza, toplam 109 (kız/erkek: 58/51) hasta dâhil edildi. Hastaların yaş ortalaması, 9,22±4,28 (minimum-maksimum: 1,1-17,9) yıl idi. Hastaların genetik sonuçları ile hastalık skoru arasında anlamlı bir ilişki gösterilemedi. Artriti olan hastaların, artriti olmayanlara göre semptom şiddet skorları anlamlı şekilde yüksekti (p<0,001). OTH, atak döneminde ataksız döneme göre anlamlı şekilde düşüktü (7,92±0,19; 8,19±0,27 fL, p=0,001). Hastalık ağırlık şiddet skoru en yüksek olanlarda, en düşük OTH düzeyi gösterildi (p=0,048). Atak döneminde proteinürisi olan hastaların OTH düzeyleri, olmayanlara göre anlamlı düşüktü (p=0,03). Sonuç: AAA hastalarında; kolay, ucuz ve hızlı bir yöntem olan OTH ölçümünün, atak ve hastalık şiddetini belirlemede destekleyici bir parametre olabileceğini düşünmekteyiz.

Anahtar Kelimeler: Ailevi Akdeniz Ateşi; ortalama trombosit hacmi
ABSTRACT
 Objective: It has been shown that mean platelet volume (MPV) can be used as a marker in many chronic diseases, including inflammatory diseases. In our study, we aimed to examine the relationship between disease severity, genetic mutation, attack/no-attack episodes with MPV levels in children with Familial Mediterranean Fever (FMF). Material and Methods: 109 children diagnosed with FMF according to Tel-Hashomer criteria were included in the study. The patients were classified according to the Pras scoring system. Patients demographic characteristics, genetic screening results, admission complaints and complete blood count parameters, MPV levels, biochemical tests, proteinuria amounts, fibrinogen, erythrocyte sedimentation rate, C-reactive protein values were recorded separately according to their attack/without attack periods. Results: A total of 109 (female/male: 58/51) patients were included in our study. The mean age of the patients was 9.22±4.28 (minimum-maximum: 1.1-17.9) years. A significant relationship between the genetic results of the patients and the disease score could not be shown. Symptom severity scores of patients with arthritis were significantly higher than those without arthritis (p<0.001). MPV was significantly lower in the attack period compared to the attack-free period (7.92±0.19; 8.19±0.27 fL, p=0.001). Those with the highest disease severity score showed the lowest MPV level (p=0.048). MPV levels of patients with proteinuria during the attack period were lower than those without (p=0.03). Conclusion: We think that MPV measurement, which is an easy, inexpensive and fast method, can be a supportive parameter in determining the severity of attacks and disease of FMF patients.

Keywords: Familial Mediterranean Fever; mean platelet volume
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