Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Aile Hekimliği Polikliniğine Başvuran Hastalarda Bozulmuş Açlık Glukozu ve Hiperlipidemi Birlikteliğinin Retrospektif Olarak Değerlendirilmesi
Retrospective Evaluation of the Association of Impaired Fasting Glucose and Hyperlipidemia in Patients Applying to the Family Medicine Outpatient Clinic
Özlem POLATa, Özlem HARMANKAYAb, Sadık Sami HATİPOĞLUc
aSağlık Bilimleri Üniversitesi Bakırköy Dr. Sadi Konuk Eğitim Araştırma Hastanesi, Aile Hekimliği Kliniği, İstanbul, Türkiye
bBiruni Üniversitesi Tıp Fakültesi, Nefroloji BD, İstanbul, Türkiye
cSağlık Bilimleri Üniversitesi Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, İstanbul, Türkiye
Turkiye Klinikleri J Med Sci. 2022;42(3):153-8
doi: 10.5336/medsci.2022-89479
Article Language: TR
Full Text
ÖZET
 Amaç: Diyabetin erken tanı ve takibi ile sonrasında gelişebilecek metabolik bozuklukların önlenmesinde aile hekimleri önemli bir yere sahiptir. Diyabetin erken dönemi olan bozulmuş açlık glukozu (BAG) ile lipid metabolizma bozukluğu birlikteliğini inceledik. Gereç ve Yöntemler: Retrospektif olan çalışmamıza aile hekimliği polikliniğine başvuran bilinen diyabeti, dislipidemisi, kardiyovasküler hastalığı olmayan 993 hasta dâhil edildi. Olguların demografik özellikleri, açlık kan glukozu (AKG), total kolesterol, trigliserid, yüksek yoğunluklu lipoprotein [high density lipoprotein (HDL)], düşük yoğunluklu lipoprotein [low density lipoprotein (LDL)] ve hemoglobin A1c (HbA1c) parametreleri değerlendirildi. Bulgular: Çalışmaya katılanların %67,9'u kadındı ve %41,6'sında BAG vardı. Olguların %35,4'ünde (n=352) LDL; %33,6'sında (n=334) total kolesterol; %26,2'sinde (n=260) trigliserid değerleri yüksek; %51,1'inde (n=507) HDL düşük olarak saptandı. BAG görülenlerde yaş ortalamalarının ve trigliseridin yüksek olma oranının, AKG düzeyi normal olanlardan yüksek olduğu görüldü (p<0,001) (p<0,001). Erkeklerde BAG görülme oranı kadınlardan daha yüksekti (p<0,05). BAG olanların HbA1c düzeyleri, AKG düzeyi normal olanlardan yüksekti (p<0,001). LDL düzeyi, total kolesterol düzeyi ve trigliserid düzeyi yüksek olan olguların yaş ortalamaları, normal değerlere sahip olanlardan yüksek saptandı (p<0,001). Trigliserid düzeyleri yüksek olan olguların HbA1c yüzdesi düzeyleri, normal olan olgulardan yüksekti (p<0,05). Sonuç: BAG döneminde glukoz metabolizması ile birlikte lipid metabolizma bozukluğunun da başlayabileceğine dair veriler saptanmıştır. Koruyucu hekimlik uygulamalarında, erken dönemde risk altındaki hastaları belirleyerek, glukoz ve lipid metabolizması açısından takiplerinin yapılması klinik önem taşıyabilir.

Anahtar Kelimeler: Diyabet; prediyabet; bozulmuş açlık glukozu; hiperlipidemi
ABSTRACT
 Objective: Family physicians have an important place in early diagnosis and follow-up diabetes and prevention of metabolic disorders that may develop later. We examined the association of impaired fasting glucose (IFG) which is the early stage of diabetes, and lipid metabolism disorder. Material and Methods: Our retrospective study included 993 patients without known diabetes, dyslipidemia, cardiovascular disease who applied to Family medicine outpatient clinic. Demographic characteristics of the cases, fasting plasma glucose (FPG), total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL) and hemoglobin A1c (HbA1c) parameters were evaluated. Result: Of the study participants, 67.9% were women and 41.6% had IFG. LDL in 35.4% (n=352) of cases; 33.6% (n=334) of total cholesterol; 26.2 % (n=260) had high triglyceride values; HDL was found to low in 51.1% (n=507). The rate of high triglyceride levels and mean age of patients with IFG were higher than those with normal FPG levels (p<0.001) (p<0.001). The incidence of IFG in men was higher than women (p<0.05). HbA1c levels of patients with IFG were higher than with normal FPG (p<0.001). The mean age of the patients with high LDL, total cholesterol and triglyceride levels were found higher than patients with normal values (p<0.001). The HbA1c levels of the cases with abnormal triglyceride levels were higher than those with normal levels (p<0.05). Conclusion: We observed data indicating that lipid metabolism disorder may start together with glucose metabolism in IFG period. In preventive medicine practices, it may be clinically important to identify patients at risk in early period and follow them in terms of glucose and lipid metabolism.

Keywords: Diabetes; prediabetes; impaired fasting glucose; hyperlipidemia
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