Vagus Nerve Stimulation

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Acute Effects of Vagal Neuromodulation Approaches in Healthy Individuals
Sağlıklı Bireylerde Vagal Nöromodülasyon Yaklaşımlarının Akut Etkileri
Berkay Eren PEHLİVANOĞLUa , Alper PERÇİNb
aBahçeşehir University Faculty of Health Sciences, Deparment of Physiotherapy and Rehabilitation, İstanbul, Türkiye
bIğdır University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Iğdır, Türkiye
Pehlivanoğlu BE, Perçin A. Acute effects of vagal neuromodulation approaches in healthy individuals. In: Alptekin HK, ed. Vagus Nerve Stimulation. 1st ed. Ankara: Türkiye Klinikleri; 2024. p.1-6.
Article Language: EN
ABSTRACT
The acute effects of vagal neuromodulation approaches in healthy individuals play an important role in regulating the autonomic nervous system (ANS) and maintaining overall body homeostasis. The vagus nerve (VN) is the main component of the parasympathetic nervous system (PNS). Different neuromodulation techniques can produce different acute effects by modulating the activity of the VN. Vagal neuromodulation has been shown to be effective on heart rate, blood pressure and autonomic functions. The use of these approaches may have beneficial effects on stress management, mood regulation and modulation of inflammatory responses. Studies in healthy individuals show that vagal neuromodulation has rapid and transient effects, with the potential to improve autonomic balance and enhance stress coping mechanisms. Heart rate variability, pulse rate, systolic and diastolic blood pressure, respiratory rate, stress and anxiety, anti-inflammatory effects, gastrointestinal effects and autonomic reflex control can be listed as specific mechanisms that can be regulated by vagal nerve stimulation (VNS). The aim of this study is to compile the data in the literature on the applicability of the acute effects of VNS in healthy individuals and to pioneer new studies to be designed.

Keywords: Vagus nerve; vagus nerve stimulation; neural inhibitions
ÖZET
Sağlıklı bireylerde vagal nöromodülasyon yaklaşımlarının akut etkileri, otonom sinir sisteminin düzenlenmesinde ve total vücut homeostazının sağlanmasında önemli bir rol oynar. Vagus siniri (VS), parasempatik sinir sisteminin ana bileşenidir. Çeşitli nöromodülasyon teknikleri, VS'nin aktivitesini modüle ederek farklı akut etkilere yol açabilir. Vagal nöromodülasyonun; kalp hızı, kan basıncı ve otonom fonksiyonlar üzerinde etkili olduğu gösterilmiştir. Bu yaklaşımların uygulanması, stresle başa çıkma, duygu-durum regülasyonu ve inflamatuar tepkilerin modülasyonunda olumlu sonuçlar doğurabilir. Sağlıklı bireylerde yapılan araştırmalarda, vagal nöromodülasyonun hızlı ve geçici etkilere sahip olduğunu, bu etkilerin otonom dengeyi iyileştirme ve stresle başa çıkma mekanizmalarını güçlendirme potansiyeli taşıdığını göstermektedir. Kalp hızı değişkenliği, nabız, sistolik ve diastolik kan basıncı, solunum hızı, stres ve anksiyete, anti-inflamatuar etkiler, gastrointestinal etkiler ve otonom refleks kontrolü vagus sinir stimülasyonu (VSS) ile düzenlenebilecek belirli mekanizmalar olarak listelenebilmektedir. Bu çalışmanın amacı VSS'in akut etkilerinin sağlıklı bireylerde kullanılabilirliği hakkında literatürdeki veriyi derleyerek yeni kurgulanacak çalışmalara öncü olabilmektir.

Anahtar Kelimeler: Vagus siniri; vagus sinir uyarısı; nöral inhibisyonlar

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