Turkiye Klinikleri Rheumatology - Special Topics

Sistemik Skleroz Özel Sayısı
.: REVIEW
Sistemik Sklerozda Kapillaroskopi
Capillaroscopic Assesment in Systemic Sclerosis
Yasemin YALÇINKAYAa, Murat İNANÇa
aİç Hastalıkları AD, Romatoloji BD, İstanbul Üniversitesi İstanbul Tıp Fakültesi, İstanbul
Turkiye Klinikleri J Rheumatol-Special Topics. 2015;8(2):69-74
Article Language: TR
ÖZET
Sistemik skleroz (SSk) hastalığı seyrinde görülen vasküler hasar, yüksek morbidite ve mortalitenin önemli nedenlerden biri olarak kabul edilmektedir. Raynaud Fenomeni (Rf) olarak adlandırılan ve mikrovasküler hasarın kliniğe yansıması olarak kabul edilen klinik bulgunun, hastalığın diğer semptomları ortaya çıkmadan yıllarca önce var olabildiği bilinmektedir. Mikrosirkülasyondaki değişiklikler, tırnak dibi video-kapillaroskopisi (TVK) ile non-invaziv olarak görüntülenebilmektedir. Bu yöntem, erken dönemde SSk tanısını koymada ve tanısı konulmuş hastalarda mikroanjiyopatinin seyrini izlemede değerli bir teknik olarak kabul edilmiştir. TVK ile organ tutulumu ve hastalık şiddetinin öngörülebiliyor olması da, organ hasarının önlenmesi ve hastalık progresyonunun yavaşlatılmasına yönelik erken tedavi yaklaşımına katkı sağlamaktadır. Biyobelirteçler ile TVK ilişkisi araştıran çalışmaların, SSk patogenezinin aydınlatılması ile ilgili önemli bilgiler vereceği düşünülmektedir.

Anahtar Kelimeler: Sistemik skleroz; tırnak dibi video-kapillaroskopi
ABSTRACT
Vascular injury is accepted as one of the main pathogenetic mechanism responsible for high morbidity and mortality in systemic sclerosis (SSc). Raynaud's phenomenon (RP) is the initial clinical symptom reflecting the microvascular injury before the onset of other manifestations. Microvascular injury inducing structural changes of capillary array can be established by a non-invasive imaging tool, nailfold video-capillaroscopy (NVC), from the early stages of the diasese. It has been accepted as a useful method for early diagnosis of SSc and follow-up of microangiopathy in SSc. Determination of organ involvement and severity of disease by using NVC will provide earlier therapeutical approach to prevent organ injury and slow the progression of the SSc disease. The evaluation of the relationship between biomarkers and NVC findings will be informative about the patogenesis of SSc.

Keywords: Systemic sclerosis; nailfold video-capillaroscopy

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30.03.2014

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