.: ORİJİNAL ARAŞTIRMA
Relationship Between C-Reactive Protein, Uric Acid and Fibrinogen Levels and Insulin Resistance in Different Body Mass Indexes: Descriptive Research
Farklı Beden Kitle İndekslerinde C-Reaktif Protein, Ürik Asit ve Fibrinojen Düzeyleri ile İnsülin Direnci Arasındaki İlişki: Tanımlayıcı Araştırma
Turkiye Klinikleri J Cardiovasc Sci. 2023;35(1):21-6
doi: 10.5336/cardiosci.2022-94122
Makale Dili: EN
Tam Metin
Ücretsiz Erişim
ABSTRACT
Objective: Chronic inflammation in obesity is the main factor that increases insulin resistance by causing changes in insulin sensitivity. Our study aimed to investigate the relationship between insulin resistance and C-reactive protein (CRP), uric acid, and fibrinogen levels in different body mass indexes (BMI). Material and Methods: In our study, patients who applied to our hospital with the complaint of overweight in 2021-2022 were retrospectively analyzed, and 149 women aged 20 and over were included in the study. Glucose, uric acid, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglyceride (TG), CRP, insulin, fibrinogen results, which were measured simultaneously with the height and weight measurements of the patients, were obtained from the laboratory information system. Results: The patients included in the study were 25 normal weight, 56 overweight, 53 obese and 15 morbidly obese according to BMI. The uric acid and TG levels of the overweight group were found to be significantly higher than the normal group (respectively; p=0.012, p=0.031), the CRP level of the morbidly obese group was found to be significantly higher than the normal, overweight, and obese groups (respectively; p<0.001, p<0.001, p=0.006). A significant positive correlation was found between Homeostatic Model Assessment for Insulin Resistance and CRP and uric acid (respectively; r=0.219, p=0.009; r=0.353, p<0,001). Conclusion: We think that uric acid levels in the early stage of obesity and CRP levels in the advanced stage may be a guide for insulin resistance and obesity-related diseases.
Keywords: Fibrinogen; uric acid; C-reaktive protein; obesity; insulin resistance
Objective: Chronic inflammation in obesity is the main factor that increases insulin resistance by causing changes in insulin sensitivity. Our study aimed to investigate the relationship between insulin resistance and C-reactive protein (CRP), uric acid, and fibrinogen levels in different body mass indexes (BMI). Material and Methods: In our study, patients who applied to our hospital with the complaint of overweight in 2021-2022 were retrospectively analyzed, and 149 women aged 20 and over were included in the study. Glucose, uric acid, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglyceride (TG), CRP, insulin, fibrinogen results, which were measured simultaneously with the height and weight measurements of the patients, were obtained from the laboratory information system. Results: The patients included in the study were 25 normal weight, 56 overweight, 53 obese and 15 morbidly obese according to BMI. The uric acid and TG levels of the overweight group were found to be significantly higher than the normal group (respectively; p=0.012, p=0.031), the CRP level of the morbidly obese group was found to be significantly higher than the normal, overweight, and obese groups (respectively; p<0.001, p<0.001, p=0.006). A significant positive correlation was found between Homeostatic Model Assessment for Insulin Resistance and CRP and uric acid (respectively; r=0.219, p=0.009; r=0.353, p<0,001). Conclusion: We think that uric acid levels in the early stage of obesity and CRP levels in the advanced stage may be a guide for insulin resistance and obesity-related diseases.
Keywords: Fibrinogen; uric acid; C-reaktive protein; obesity; insulin resistance
ÖZET
Amaç: Obezitede görülen kronik inflamasyon, insülin duyarlılığında değişikliğe neden olarak insülin direncini artıran temel faktördür. Çalışmamızda, farklı beden kitle indekslerinde (BKİ) insülin direnci ile C-reaktif protein (CRP), ürik asit ve fibrinojen düzeyleri arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmamızda, 2021-2022 yıllarında fazla kilo şikâyeti ile hastanemize başvuran hastalar retrospektif olarak incelendi ve 20 yaş ve üzeri 149 kadın çalışmaya dâhil edildi. Hastaların boy ve kilo ölçümleri ile eş zamanlı olarak ölçülen glukoz, ürik asit, total kolesterol, yüksek dansiteli lipoprotein kolesterol, düşük dansiteli lipoprotein kolesterol, trigliserid (TG), CRP, insülin ve fibrinojen sonuçları laboratuvar bilgi sisteminden alındı. Bulgular: Çalışmaya dâhil edilen hastalar BKİ'ye göre 25 normal kilolu, 56 kilolu, 53 obez ve 15 morbid obezdi. Aşırı kilolu grubun ürik asit ve TG düzeyleri normal kilolu gruba göre anlamlı olarak yüksek (sırasıyla; p=0,012, p=0,031), morbid obez grubun CRP düzeyi normal, fazla kilolu ve obez gruplara göre anlamlı yüksek bulundu (sırasıyla p<0,001, p<0,001, p=0,006). İnsülin Direncinin Homeostatik Modeli Değerlendirmesi ile CRP ve ürik asit arasında anlamlı pozitif korelasyon saptandı (sırasıyla; r=0,219, p=0,009; r=0,353, p<0,001). Sonuç: Obezitenin erken evresinde ürik asit, ileri evresinde ise CRP düzeylerinin, insülin direnci ve obezite ile ilişkili hastalıklar için yol gösterici olabileceğini düşünüyoruz.
Anahtar Kelimeler: Fibrinojen; ürik asit; C-reaktif protein; obezite; insülin direnci
Amaç: Obezitede görülen kronik inflamasyon, insülin duyarlılığında değişikliğe neden olarak insülin direncini artıran temel faktördür. Çalışmamızda, farklı beden kitle indekslerinde (BKİ) insülin direnci ile C-reaktif protein (CRP), ürik asit ve fibrinojen düzeyleri arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmamızda, 2021-2022 yıllarında fazla kilo şikâyeti ile hastanemize başvuran hastalar retrospektif olarak incelendi ve 20 yaş ve üzeri 149 kadın çalışmaya dâhil edildi. Hastaların boy ve kilo ölçümleri ile eş zamanlı olarak ölçülen glukoz, ürik asit, total kolesterol, yüksek dansiteli lipoprotein kolesterol, düşük dansiteli lipoprotein kolesterol, trigliserid (TG), CRP, insülin ve fibrinojen sonuçları laboratuvar bilgi sisteminden alındı. Bulgular: Çalışmaya dâhil edilen hastalar BKİ'ye göre 25 normal kilolu, 56 kilolu, 53 obez ve 15 morbid obezdi. Aşırı kilolu grubun ürik asit ve TG düzeyleri normal kilolu gruba göre anlamlı olarak yüksek (sırasıyla; p=0,012, p=0,031), morbid obez grubun CRP düzeyi normal, fazla kilolu ve obez gruplara göre anlamlı yüksek bulundu (sırasıyla p<0,001, p<0,001, p=0,006). İnsülin Direncinin Homeostatik Modeli Değerlendirmesi ile CRP ve ürik asit arasında anlamlı pozitif korelasyon saptandı (sırasıyla; r=0,219, p=0,009; r=0,353, p<0,001). Sonuç: Obezitenin erken evresinde ürik asit, ileri evresinde ise CRP düzeylerinin, insülin direnci ve obezite ile ilişkili hastalıklar için yol gösterici olabileceğini düşünüyoruz.
Anahtar Kelimeler: Fibrinojen; ürik asit; C-reaktif protein; obezite; insülin direnci
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