Objective: Psoriasis is a chronic inflammatory disease and clinical symptoms start during childhood in about one third of the patients. The aim of this study is to investigate the existence of inexpensive and easily applicable laboratory parameters that can be used in the evaluation of disease activity and severity in childhood psoriasis. Material and Methods: This retrospective study included 72 psoriatic patients who admitted to the dermatology outpatient clinic of a tertiary university hospital within one year and 45 healthy controls under 18 years of age. Demographic and clinical data were recorded from files. Erythrocyte sedimentation rate (ESR), C-reactive protein, white blood cell (WBC), lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV) value were recorded and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio were calculated and noted. Results: The study included totally 117 children; 72 (45 females, 27 males) patients and 45 (23 females, 22 males) controls. In the patient group, 42 (58.3%) children had plaque type and 30 (41.7%) children had guttate type psoriasis. ESR, WBC, neutrophil counts, MPV and NLR values were significantly higher in the patient group than the control group (p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, respectively). NLR was found to be higher in plaque type psoriatic patients compared to control group (p=0.005). Conclusion: WBC, neutrophil count, MPV and NLR values can be alternative parameters for the assesment of the disease activity in pediatric psoriasis.
Keywords: Psoriasis; pediatric psoriasis; neutrophil/lymphocyte ratio; mean platelet volume
Amaç: Psöriyazis; kronik inflamatuar bir hastalık olup, hastaların yaklaşık 1/3'ünde klinik belirtiler çocukluk döneminde başlar. Bu çalışmanın amacı, çocukluk psöriyazisinde hastalık aktivite ve şiddetini değerlendirmede kullanılabilecek ucuz ve kolay ulaşılabilir laboratuvar parametrelerinin varlığını araştırmaktır. Gereç ve Yöntemler: Bu retrospektif çalışmaya, 1 yıllık süre zarfında 3. basamak bir sağlık kuruluşunun dermatoloji polikliniğine ayaktan başvuran 18 yaş altı 72 psöriyazis tanılı hasta ile 45 sağlıklı kontrol dâhil edildi. Demografik ve klinik veriler dosyalar taranarak kaydedildi. Eritrosit sedimantasyon hızı (ESH), C-reaktif protein, beyaz kan hücresi [white blood cell (WBC)], lenfosit, nötrofil, platelet sayıları, ortalama platelet hacmi [mean platelet volume (MPV)] değerleri kaydedildi ve nötrofil/lenfosit oranı [neutrophil/lymphocyte ratio (NLR)], platelet/lenfosit oranı hesaplanarak not edildi. Bulgular: Bu çalışmaya 117 çocuk dâhil edilmiş olup, bunların 72'si (45 kız, 27 erkek) hasta, 45'i (23 kız, 22 erkek) kontrol grubundaydı. Hasta grubunda, 42 (%58,3) çocukta plak tip, 30'unda (%41,7) guttat tip psöriyazis vardı. ESH, WBC, nötrofil sayısı, MPV ve NLR değerleri hasta grubunda kontrol grubuna kıyasla anlamlı oranda yüksekti (sırasıyla p<0,001, p<0,001, p<0,001, p<0,001, p=0,002). NLR, plak tip psöriyazis hastalarında kontrol grubuna kıyasla anlamlı oranda yüksekti (p=0,005). Sonuç: WBC, nötrofil sayısı, MPV ve NLR, pediatrik psöriyaziste hastalık aktivitesini değerlendirmede kullanılabilecek alternatif parametreler olabilir.
Anahtar Kelimeler: Psöriyazis; pediatrik psöriyazis; nötrofil/lenfosit oranı; ortalama platelet hacmi
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