Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Mean Platelet Volume in Pediatric Psoriasis Patients: A Descriptive Study
Pediatrik Psöriyazis Hastalarında Nötrofil/Lenfosit Oranı, Platelet/Lenfosit Oranı ve Ortalama Platelet Hacminin Değerlendirilmesi: Tanımlayıcı Bir Çalışma
Atiye AKBAYRAKa, Havva YILDIZ SEÇKİNa, Tuba KASAPb , Zennure TAKÇIa, Osman DEMİRc, Ali GÜLb , Ergün SÖNMEZGÖZb
aDepartment of Dermatology and Venereology, Gaziosmanpasa University Faculty of Medicine, Tokat, Türkiye
bDepartment of Pediatrics, Gaziosmanpasa University Faculty of Medicine, Tokat, Türkiye
cDepartment of Biostatistics, Gaziosmanpasa University Faculty of Medicine, Tokat, Türkiye
Turkiye Klinikleri J Dermatol. 2023;33(1):14-20
doi: 10.5336/dermato.2022-92905
Article Language: EN
Full Text
ABSTRACT
Objective: Psoriasis is a chronic inflammatory disease and clinical symptoms start during childhood in about one third of the patients. The aim of this study is to investigate the existence of inexpensive and easily applicable laboratory parameters that can be used in the evaluation of disease activity and severity in childhood psoriasis. Material and Methods: This retrospective study included 72 psoriatic patients who admitted to the dermatology outpatient clinic of a tertiary university hospital within one year and 45 healthy controls under 18 years of age. Demographic and clinical data were recorded from files. Erythrocyte sedimentation rate (ESR), C-reactive protein, white blood cell (WBC), lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV) value were recorded and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio were calculated and noted. Results: The study included totally 117 children; 72 (45 females, 27 males) patients and 45 (23 females, 22 males) controls. In the patient group, 42 (58.3%) children had plaque type and 30 (41.7%) children had guttate type psoriasis. ESR, WBC, neutrophil counts, MPV and NLR values were significantly higher in the patient group than the control group (p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, respectively). NLR was found to be higher in plaque type psoriatic patients compared to control group (p=0.005). Conclusion: WBC, neutrophil count, MPV and NLR values can be alternative parameters for the assesment of the disease activity in pediatric psoriasis.

Keywords: Psoriasis; pediatric psoriasis; neutrophil/lymphocyte ratio; mean platelet volume
ÖZET
Amaç: Psöriyazis; kronik inflamatuar bir hastalık olup, hastaların yaklaşık 1/3'ünde klinik belirtiler çocukluk döneminde başlar. Bu çalışmanın amacı, çocukluk psöriyazisinde hastalık aktivite ve şiddetini değerlendirmede kullanılabilecek ucuz ve kolay ulaşılabilir laboratuvar parametrelerinin varlığını araştırmaktır. Gereç ve Yöntemler: Bu retrospektif çalışmaya, 1 yıllık süre zarfında 3. basamak bir sağlık kuruluşunun dermatoloji polikliniğine ayaktan başvuran 18 yaş altı 72 psöriyazis tanılı hasta ile 45 sağlıklı kontrol dâhil edildi. Demografik ve klinik veriler dosyalar taranarak kaydedildi. Eritrosit sedimantasyon hızı (ESH), C-reaktif protein, beyaz kan hücresi [white blood cell (WBC)], lenfosit, nötrofil, platelet sayıları, ortalama platelet hacmi [mean platelet volume (MPV)] değerleri kaydedildi ve nötrofil/lenfosit oranı [neutrophil/lymphocyte ratio (NLR)], platelet/lenfosit oranı hesaplanarak not edildi. Bulgular: Bu çalışmaya 117 çocuk dâhil edilmiş olup, bunların 72'si (45 kız, 27 erkek) hasta, 45'i (23 kız, 22 erkek) kontrol grubundaydı. Hasta grubunda, 42 (%58,3) çocukta plak tip, 30'unda (%41,7) guttat tip psöriyazis vardı. ESH, WBC, nötrofil sayısı, MPV ve NLR değerleri hasta grubunda kontrol grubuna kıyasla anlamlı oranda yüksekti (sırasıyla p<0,001, p<0,001, p<0,001, p<0,001, p=0,002). NLR, plak tip psöriyazis hastalarında kontrol grubuna kıyasla anlamlı oranda yüksekti (p=0,005). Sonuç: WBC, nötrofil sayısı, MPV ve NLR, pediatrik psöriyaziste hastalık aktivitesini değerlendirmede kullanılabilecek alternatif parametreler olabilir.

Anahtar Kelimeler: Psöriyazis; pediatrik psöriyazis; nötrofil/lenfosit oranı; ortalama platelet hacmi
REFERENCES:
  1. Bronckers IM, Paller AS, van Geel MJ, van de Kerkhof PC, Seyger MM. Psoriasis in children and adolescents: diagnosis, management and comorbidities. Paediatr Drugs. 2015;17(5):373-84. [Crossref]  [PubMed]  [PMC] 
  2. Augustin M, Glaeske G, Radtke MA, Christophers E, Reich K, Schäfer I. Epidemiology and comorbidity of psoriasis in children. Br J Dermatol. 2010;162(3):633-6. [Crossref]  [PubMed] 
  3. Raychaudhuri SP, Gross J. A comparative study of pediatric onset psoriasis with adult onset psoriasis. Pediatr Dermatol. 2000;17(3):174-8. [Crossref]  [PubMed] 
  4. Korman NJ. Management of psoriasis as a systemic disease: what is the evidence? Br J Dermatol. 2020;182(4):840-8. [Crossref]  [PubMed]  [PMC] 
  5. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372-6. [Crossref]  [PubMed] 
  6. Polat M, Bugdayci G, Kaya H, Oğuzman H. Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in Turkish patients with chronic plaque psoriasis. Acta Dermatovenerol Alp Pannonica Adriat. 2017;26(4):97-100. [Crossref]  [PubMed] 
  7. Çiçek G, Açıkgoz SK, Bozbay M, Altay S, Uğur M, Uluganyan M, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Angiology. 2015;66(5):441-7. [Crossref]  [PubMed] 
  8. Volf EM, Levine DE, Michelon MA, Au SC, Patvardhan E, Dumont N, et al. Assessor-blinded study of the metabolic syndrome and surrogate markers of increased cardiovascular risk in children with moderate-to-severe psoriasis compared with age-matched population of children with warts. J Drugs Dermatol. 2011;10(8):900-1. [PubMed] 
  9. Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Mater Sociomed. 2014;26(4):231-3. [Crossref]  [PubMed]  [PMC] 
  10. Niknezhad N, Haghighatkhah HR, Zargari O, Ghalamkarpour F, Younespour S, Niknejad N, et al. High-sensitivity C-reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis. Dermatol Ther. 2020;33(4):e13628. [Crossref]  [PubMed] 
  11. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol. 2014;33(3):223-7. [Crossref]  [PubMed] 
  12. Canpolat F, Akpinar H, Eskioğlu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29(3):325-8. [Crossref]  [PubMed] 
  13. Yurtdaş M, Yaylali YT, Kaya Y, Ozdemir M, Ozkan I, Aladağ N. Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis. Echocardiography. 2014;31(9):1095-104. [Crossref]  [PubMed] 
  14. Paliogiannis P, Satta R, Deligia G, Farina G, Bassu S, Mangoni AA, et al. Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis. Clin Exp Med. 2019;19(1):37-45. [Crossref]  [PubMed] 
  15. Unal M, Kucuk A, Urun Unal G, Balevi Ş, Tol H, Aykol C, et al. Mean platelet volume, neutrophil to lyphocyte ratio and platelet tolymphocyte ratio in psoriasis. Turkderm-Turk Arch Dermatol Venereol. 2015;49(2):112-6. [Crossref] 
  16. Kim DS, Shin D, Lee MS, Kim HJ, Kim DY, Kim SM, et al. Assessments of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in Korean patients with psoriasis vulgaris and psoriatic arthritis. J Dermatol. 2016;43(3):305-10. [Crossref]  [PubMed] 
  17. Paulus JM. Platelet size in man. Blood. 1975;46(3):321-36. [Crossref]  [PubMed] 
  18. Uyanik B, Kavalci C, Arslan ED, Yilmaz F, Aslan O, Dede S, et al. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int. 2012;2012:823095. [Crossref]  [PubMed]  [PMC] 
  19. Yi P, Jiang J, Wang Z, Wang X, Zhao M, Wu H, et al. Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: a systematic review and meta-analysis. PLoS One. 2022;17(2):e0264504. [Crossref]  [PubMed]  [PMC] 
  20. Li L, Yu J, Zhou Z. Platelet-associated parameters in patients with psoriasis: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2021;100(50):e28234. [Crossref]  [PubMed] 
  21. Mondal S, Guha S, Saha A, Ghoshal L, Bandyopadhyay D. Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic plaque psoriasis. Indian J Dermatol. 2022;67(4):477. [PubMed]  [PMC] 
  22. Asahina A, Kubo N, Umezawa Y, Honda H, Yanaba K, Nakagawa H. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: Response to therapy with biologics. J Dermatol. 2017;44(10):1112-21. [Crossref]  [PubMed] 
  23. Erek Toprak A, Ozlu E, Uzuncakmak TK, Yalcınkaya E, Sogut S, Karadag AS. Neutrophil/lymphocyte ratio, serum endocan, and nesfatin-1 levels in patients with psoriasis vulgaris undergoing phototherapy treatment. Med Sci Monit. 2016;22:1232-7. [Crossref]  [PubMed]  [PMC] 

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